Sleep quality in acromegaly and changes after transsphenoidal surgery: a prospective longitudinal study

被引：8

作者：

Zhang, Yi ^{[1
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]}

Guo, Xiaopeng ^{[1
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]}

Guo, Jinzhu ^{[1
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]}

Wang, Lijun ^{[1
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]}

Zhao, Haiyan ^{[1
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]}

Wang, Yanyan ^{[1
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]}

Wang, Jike ^{[1
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,4
]}

Sun, Xuefei ^{[1
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]}

Jiang, Wenwen ^{[1
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]}

Liu, Ge ^{[1
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]}

Xiao, Zhiyuan ^{[1
,2
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]}

Cong, Nan ^{[1
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,4
]}

Qi, Jiwei ^{[1
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,3
,4
]}

Han, Shiyuan ^{[1
,2
,3
,4
]}

Wang, Zihao ^{[1
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,4
]}

Gao, Lu ^{[1
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]}

Bao, Xinjie ^{[1
,2
,3
,4
]}

Feng, Ming ^{[1
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]}

Yao, Yong ^{[1
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Deng, Kan ^{[1
,2
,3
,4
]}

Lian, Wei ^{[1
,2
,3
,4
]}

Xing, Bing ^{[1
,2
,3
,4
]}

机构：

[1] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Neurosurg, Beijing 100730, Peoples R China

[2] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Key Lab Endocrinol, Minist Hlth, Beijing 100730, Peoples R China

[3] China Pituitary Dis Registry Ctr, Beijing 100730, Peoples R China

[4] China Pituitary Adenoma Specialist Council, Beijing 100730, Peoples R China

来源：

SLEEP MEDICINE | 2020年 / 67卷

关键词：

Acromegaly; Sleep quality; Pittsburgh Sleep Quality Index; Transsphenoidal surgery; Emotional problems; APNEA SYNDROME; ABNORMALITIES; INSTRUMENT; INDEX;

D O I：

10.1016/j.sleep.2019.11.1256

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective: To elucidate the sleep quality characteristics and factors related to either good or poor sleep quality in acromegaly patients before surgery and to explore sleep quality changes after transsphenoidal surgery and the factors related to these changes. Methods: We prospectively enrolled 39 acromegaly patients and 78 patients with nonfunctioning pituitary adenomas. Scales for anxiety, depression, disease stigma and nasal condition were evaluated. The Pittsburgh Sleep Quality Index (PSQI) questionnaire was administered before surgery as well as one month and three months after surgery. Results: A higher percentage of acromegaly patients had poor sleep quality compared to controls (35.9% vs. 5.1%, p < 0.001). In addition, acromegaly patients experienced worse subjective sleep quality, extended sleep latency, increased sleep disturbance and decreased daytime functioning. Higher scores for anxiety, disease stigma and sinonasal outcomes were correlated with worse sleep quality in acromegaly patients. At one month after transsphenoidal surgery, we found worse subjective sleep quality, extended sleep latency, shortened sleep duration, impaired sleep efficiency and increased sleep disturbance in acromegaly patients. At three months postoperatively, most impaired PSQI domains in acromegaly patients recovered to preoperative levels. The use of soluble gauze was related to decreased sleep quality at one month after surgery and severe anxiety and depression were related to improved sleep quality at three months after surgery. Conclusions: Sleep quality was reduced in acromegaly patients. Moreover, sleep quality initially worsened after surgery but later recovered. Emotional problems and the use of soluble gauze were related factors. (C) 2019 Elsevier B.V. All rights reserved.

引用

页码：164 / 170

页数：7

共 31 条

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