Antimicrobial peptides: mechanism of action, activity and clinical potential

被引：579
作者：
Zhang, Qi-Yu [1 ]
Yan, Zhi-Bin
Meng, Yue-Ming [1 ]
Hong, Xiang-Yu [1 ]
Shao, Gang [2 ]
Ma, Jun-Jie [1 ]
Cheng, Xu-Rui [1 ]
Liu, Jun [3 ,4 ]
Kang, Jian [5 ,6 ]
Fu, Cai-Yun [1 ]
机构：
[1] Zhejiang Sci Tech Univ, Coll Life Sci & Med, Zhejiang Prov Key Lab Silkworm Bioreactor & Biome, 928 St 2,Xiasha Higher Educ Zone, Hangzhou 310018, Zhejiang, Peoples R China
[2] 903rd Hosp PLA, Dept Oncol, Hangzhou 310013, Zhejiang, Peoples R China
[3] Univ Calif San Francisco, Dept Pharmaceut Chem, 555 Mission Bay Blvd South, San Francisco, CA 94158 USA
[4] Univ Calif San Francisco, Cardiovasc Res Inst, 555 Mission Bay Blvd South, San Francisco, CA 94158 USA
[5] Peter MacCallum Canc Ctr, Oncogen Signaling & Growth Control Program, 305 Grattan St, Melbourne, Vic 3000, Australia
[6] Univ Melbourne, Sir Peter MacCallum Dept Oncol, Parkville, Vic 3010, Australia
来源：
MILITARY MEDICAL RESEARCH | 2021年 / 8卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Antimicrobial peptides; Antimicrobial resistance; Mechanism of action; Biological activity; Clinical application; HUMAN NEUTROPHIL PEPTIDE-1; HOST-DEFENSE PEPTIDES; HUMAN CATHELICIDIN LL-37; HERPES-SIMPLEX-VIRUS; COLON-CANCER CELLS; STAPHYLOCOCCUS-AUREUS; ESCHERICHIA-COLI; THETA-DEFENSINS; IN-VITRO; HUMAN BETA-DEFENSIN-3;
D O I：
10.1186/s40779-021-00343-2
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The management of bacterial infections is becoming a major clinical challenge due to the rapid evolution of antibiotic resistant bacteria. As an excellent candidate to overcome antibiotic resistance, antimicrobial peptides (AMPs) that are produced from the synthetic and natural sources demonstrate a broad-spectrum antimicrobial activity with the high specificity and low toxicity. These peptides possess distinctive structures and functions by employing sophisticated mechanisms of action. This comprehensive review provides a broad overview of AMPs from the origin, structural characteristics, mechanisms of action, biological activities to clinical applications. We finally discuss the strategies to optimize and develop AMP-based treatment as the potential antimicrobial and anticancer therapeutics.
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页数：25
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