Mitophagy in Alzheimer's Disease and Other Age-Related Neurodegenerative Diseases

被引：200

作者：

Cai, Qian ^{[1
]}

Jeong, Yu Young ^{[1
]}

机构：

[1] Rutgers State Univ, Dept Cell Biol & Neurosci, Piscataway, NJ 08854 USA

来源：

CELLS | 2020年 / 9卷 / 01期

基金：

美国国家卫生研究院;

关键词：

mitophagy; mitophagosome; lysosome; mitochondrial dynamics; mitochondrial quality control; Alzheimer's disease; Parkinson's disease; Huntington's disease; amyotrophic lateral sclerosis; aging; ABNORMAL MITOCHONDRIAL DYNAMICS; AMYOTROPHIC-LATERAL-SCLEROSIS; TARGETED ANTIOXIDANT MITOQ; QUALITY-CONTROL MECHANISMS; ALPHA-SYNUCLEIN OLIGOMERS; INCLUSION-BODY FORMATION; PARKIN-DEFICIENT MICE; BETA-AMYLOID PEPTIDES; SPINAL MOTOR-NEURONS; OXIDATIVE STRESS;

D O I：

10.3390/cells9010150

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mitochondrial dysfunction is a central aspect of aging and neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and Huntington's disease. Mitochondria are the main cellular energy powerhouses, supplying most of ATP by oxidative phosphorylation, which is required to fuel essential neuronal functions. Efficient removal of aged and dysfunctional mitochondria through mitophagy, a cargo-selective autophagy, is crucial for mitochondrial maintenance and neuronal health. Mechanistic studies into mitophagy have highlighted an integrated and elaborate cellular network that can regulate mitochondrial turnover. In this review, we provide an updated overview of the recent discoveries and advancements on the mitophagy pathways and discuss the molecular mechanisms underlying mitophagy defects in Alzheimer's disease and other age-related neurodegenerative diseases, as well as the therapeutic potential of mitophagy-enhancing strategies to combat these disorders.

引用

页数：28

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