Autologous haematopoietic stem cell transplantation in POEMS syndrome:: results in 4 cases

被引：5

作者：

Abrisqueta, Pau ^{[1
]}

Rovira, Montserrat ^{[1
]}

Cibeira, Maria Teresa ^{[1
]}

Vallansot, Rolando ^{[1
]}

Gutierrez, Gonzalo ^{[1
]}

Blade, Joan ^{[1
]}

Carreras, Enric ^{[1
]}

Montserrat, Ernili ^{[1
]}

机构：

[1] Univ Barcelona, Hosp Clin Barcelona, Hematol Serv, Inst Hematol & Oncol,Unidad TPH,IDIBAPS, E-08036 Barcelona, Spain

来源：

MEDICINA CLINICA | 2007年 / 129卷 / 15期

关键词：

POEMS syndrome; autologous haematopoietic stem cell transplantation; polyneuropathy; plasma cell dyscrasia; osteosclerotic myeloma; VEGF;

D O I：

10.1157/13111711

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

POEMS (polyneuropathy, organomegaly, endocrinopathy, M protein, skin changes) syndrome is a rare disorder characterized by a clonal plasma cell proliferation with a monoclonal protein typically small and lambda restricted. Clinically, this syndrome is a multisystemic disease whose major clinical feature is a peripheral polyneuropathy. A specific treatment for this does not exist. We report 4 patients with POEMS syndrome treated with an autologous haematopoietic stem cell transplantation in our centre. All patients had an improvement in neurologic symptoms and other manifestations of the syndrome. The monoclonal component and bone lesions decreased or disappeared. In conclusion, autologous haematopoietic stem cell transplantation is an effective therapy in patients with POEMS syndrome.

引用

页码：578 / 581

页数：4

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