Modulation of an RNA-branching deoxyribozyme by a small molecule

被引:6
作者
Alila, Kennedy O. [1 ]
Baum, Dana A. [1 ]
机构
[1] St Louis Univ, Dept Chem, St Louis, MO 63103 USA
关键词
DNA ENZYMES; DNAZYME; PREDICTION; ADENOSINE; RIBOZYMES; SWITCHES; DEVICES; COMPLEX; ATP;
D O I
10.1039/c0cc04971a
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
We have engineered an RNA-branching deoxyribozyme to respond positively to ATP, resulting in modulated control of ligation activity that may be applicable to sensor and nanotechnology applications.
引用
收藏
页码:3227 / 3229
页数:3
相关论文
共 24 条
[1]   A deoxyribozyme that forms a three-helix-junction complex with its RNA substrates and has general RNA branch-forming activity [J].
Coppins, RL ;
Silverman, SK .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (09) :2900-2907
[2]   A DNA enzyme that mimics the first step of RNA splicing [J].
Coppins, RL ;
Silverman, SK .
NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2004, 11 (03) :270-274
[3]   A DNA METALLOENZYME WITH DNA-LIGASE ACTIVITY [J].
CUENOUD, B ;
SZOSTAK, JW .
NATURE, 1995, 375 (6532) :611-614
[4]  
Elbaz J, 2010, NAT NANOTECHNOL, V5, P417, DOI [10.1038/nnano.2010.88, 10.1038/NNANO.2010.88]
[5]   Functional DNAzymes organized into two-dimensional arrays [J].
Garibotti, Alejandra V. ;
Knudsen, Scott M. ;
Ellington, Andrew D. ;
Seeman, Nadrian C. .
NANO LETTERS, 2006, 6 (07) :1505-1507
[6]   A DNA APTAMER THAT BINDS ADENOSINE AND ATP [J].
HUIZENGA, DE ;
SZOSTAK, JW .
BIOCHEMISTRY, 1995, 34 (02) :656-665
[7]   A binary deoxyribozyme for nucleic acid analysis [J].
Kolpashchikov, Dmitry M. .
CHEMBIOCHEM, 2007, 8 (17) :2039-2042
[8]   A Complex RNA-Cleaving DNAzyme That Can Efficiently Cleave a Pyrimidine-Pyrimidine Junction [J].
Lam, Jeffrey C. F. ;
Withers, Johanna B. ;
Li, Yingfu .
JOURNAL OF MOLECULAR BIOLOGY, 2010, 400 (04) :689-701
[9]   ATP-dependent allosteric DNA enzymes [J].
Levy, M ;
Ellington, AD .
CHEMISTRY & BIOLOGY, 2002, 9 (04) :417-426
[10]   Selection of deoxyribozyme ligases that catalyze the formation of an unnatural internucleotide linkage [J].
Levy, M ;
Ellington, AD .
BIOORGANIC & MEDICINAL CHEMISTRY, 2001, 9 (10) :2581-2587