Phenolic profile by HPLC-ESI-MS/MS and enzymatic inhibitory effect of Bryophyllum delagoense

被引：9

作者：

Katrucha, Edenize Maria ^{[1
]}

Lopes, Jessica ^{[1
]}

Paim, Milena ^{[2
]}

dos Santos, Julia Candiani ^{[1
]}

Siebert, Diogo Alexandre ^{[3
]}

Micke, Gustavo Amadeu ^{[3
]}

Vitali, Luciano ^{[3
]}

Alberton, Michele Debiasi ^{[2
]}

Tenfen, Adrielli ^{[1
]}

机构：

[1] UniSociesc, Soc Educ Santa Catariana, Curso Grad Farm, Jaragu Do Sul, SC, Brazil

[2] Fundacao Univ Reg Blumenau, Curso Grad Farm, Blumenau, SC, Brazil

[3] Univ Fed Santa Catarina, Curso Posgrad Quim, Florianopolis, SC, Brazil

来源：

NATURAL PRODUCT RESEARCH | 2021年 / 35卷 / 22期

关键词：

Phenolic compounds; Bryophyllum; glucosidase inhibitors; ACETYLCHOLINESTERASE INHIBITORS; ALZHEIMERS;

D O I：

10.1080/14786419.2020.1729147

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Bryophyllum delagoense (Eckl. & Zeyh.) Druce, native to Madagascar, is popularly known as "abyssian cactus" and popularly used in folk medicine as an analgesic and healing agent. The study methodology was divided into the phytochemical study: fractionation and identification of phenolic compounds by HLPC-ESI-MS/MS from the methanolic extract (ME), and fractions (DCMF and EAF) of leaves of B. delagoense, and biological activity with acetylcholinesterase and alpha-glucosidase inhibition of extracts and fractions by in vitro enzymatic techniques. Twenty-seven phenolic compounds were identified, being the highest concentration of syringic acid (87.848 mg g(-1)). The DCMF fraction showed the best biological activity for inhibition of alpha-glucosidase enzyme (0.125 mg mL(-1)).

引用

页码：4824 / 4827

页数：4

共 14 条

[1] Araujo ERD, 2019, BIOMED PHARMACOTHER, V113, P1
[2] Functional significance and structure-activity relationship of food-derived α-glucosidase inhibitors
Di Stefano, Elisa
Oliviero, Teresa
Udenigwe, Chibuike C.
[J]. CURRENT OPINION IN FOOD SCIENCE, 2018, 20 : 7 - 12
[3] Recent Applications of the Multi-Target Directed Ligands Approach for the Treatment of Alzheimer's Disease
Dias, Kris Simone T.
de Paula, Cynthia T.
Riquiel, Mariana M.
do Lago, Samara T. L.
Costa, Karla Cristinne M.
Vaz, Sarah M.
Machado, Rafael P.
de Lima, Lais M. S.
Viegas, Claudio, Jr.
[J]. REVISTA VIRTUAL DE QUIMICA, 2015, 7 (02) : 609 - 648
[4] Kalanchoe laciniata and Bryophyllum pinnatum: an updated review about ethnopharmacology, phytochemistry, pharmacology and toxicology
Fernandes, Julia M.
Cunha, Lorena M.
Azevedo, Eduardo Pereira
Lourenco, Estela M. G.
Fernandes-Pedrosa, Matheus F.
Zucolotto, Silvana M.
[J]. REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, 2019, 29 (04): : 529 - 558
[5] Bioactivity-guided isolation of antidiabetic principles from the methanolic leaf extract of Bryophyllum pinnatum
Ibitoye, O. B.
Olofinsan, K. A.
Terali, K.
Ghali, U. M.
Ajiboye, T. O.
[J]. JOURNAL OF FOOD BIOCHEMISTRY, 2018, 42 (05)
[6] Flavonoids as acetylcholinesterase inhibitors: Current therapeutic standing and future prospects
Khan, Haroon
Marya
Amin, Surriya
Kamal, Mohammad Amjad
Patel, Seema
[J]. BIOMEDICINE & PHARMACOTHERAPY, 2018, 101 : 860 - 870
[7] In vitro neuroprotective effects of naringenin nanoemulsion against β-amyloid toxicity through the regulation of amyloidogenesis and tau phosphorylation
Md, Shadab
Gan, Sook Yee
Haw, Yong Hong
Ho, Chee Liang
Wong, Sinrun
Choudhury, Hira
[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2018, 118 : 1211 - 1219
[8] Morais S.M, 2013, Rev. bras. plantas med., V15, P575, DOI 10.1590/S1516-05722013000400014
[9] Nayak BS, 2010, INDIAN J EXP BIOL, V48, P572
[10] Two diseases, one approach: multitarget drug discovery in Alzheimer's and neglected tropical diseases
Prati, F.
Uliassi, E.
Bolognesi, M. L.
[J]. MEDCHEMCOMM, 2014, 5 (07) : 853 - 861

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