Simplicity and complexity in the cyanobacterial circadian clock mechanism

被引:30
|
作者
Dong, Guogang [1 ]
Kim, Yong-Ick [1 ]
Golden, Susan S. [1 ]
机构
[1] Univ Calif San Diego, Ctr Chronobiol, La Jolla, CA 92093 USA
基金
美国国家卫生研究院;
关键词
GENE-EXPRESSION; KAIC PHOSPHORYLATION; CELL-DIVISION; CRYSTAL-STRUCTURE; OUTPUT PATHWAYS; ATPASE ACTIVITY; PROTEIN; OSCILLATOR; RHYTHMS; FEEDBACK;
D O I
10.1016/j.gde.2010.09.002
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The circadian clock of the cyanobacterium Synechococcus elongatus PCC 7942 is built on a three-protein central oscillator that can be reconstituted in vitro, a redox-sensitive input for synchronization with the environment, and a bacterial two-component signal transduction pathway for global transcriptional regulation. This review covers the most recent progress in our understanding of the biological and biochemical mechanism of this bacterial clock, such as the discovery of a quinone-binding activity of the oscillator protein KaiA, the molecular mechanism of circadian control of cell division, and the global control of gene expression via modulation of DNA topology.
引用
收藏
页码:619 / 625
页数:7
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