Concise Review: Developing Best-Practice Models for the Therapeutic Use of Extracellular Vesicles

被引：256

作者：

Reiner, Agnes T. ^{[1
]}

Witwer, Kenneth W. ^{[2
,3
]}

van Balkom, Bas W. M. ^{[4
]}

de Beer, Joel ^{[5
]}

Brodie, Chaya ^{[6
,7
]}

Corteling, Randolph L. ^{[8
]}

Gabrielsson, Susanne ^{[9
]}

Gimona, Mario ^{[10
,11
]}

Ibrahim, Ahmed G. ^{[12
]}

de Kleijn, Dominique ^{[13
,14
]}

Lai, Charles P. ^{[15
]}

Lotvall, Jan ^{[16
,17
]}

del Portillo, Hernando A. ^{[18
,19
]}

Reischl, Ilona G. ^{[20
,21
]}

Riazifar, Milad ^{[22
,23
]}

Salomon, Carlos ^{[24
,25
]}

Tahara, Hidetoshi ^{[26
]}

Toh, Wei Seong ^{[27
]}

Wauben, Marca H. M. ^{[28
]}

Yang, Vicky K. ^{[29
]}

Yang, Yijun ^{[30
]}

Yeo, Ronne Wee Yeh ^{[31
]}

Yin, Hang ^{[32
,33
,34
]}

Giebel, Bernd ^{[35
]}

Rohde, Eva ^{[10
,11
]}

Lim, Sai Kiang ^{[31
]}

机构：

[1] AIT Austrian Inst Technol, BioSensor Technol, Vienna, Austria

[2] Johns Hopkins Univ, Sch Med, Dept Mol & Comparat Pathobiol, Baltimore, MD USA

[3] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

[4] Univ Med Ctr Utrecht, Dept Nephrol & Hypertens, Utrecht, Netherlands

[5] Anjarium Biosciences AG, Zollikon, Switzerland

[6] Henry Ford Hosp, Dept Neurosurg, Detroit, MI 48202 USA

[7] Bar Ilan Univ, Fac Life Sci, Ramat Gan, Israel

[8] ReNeuron Grp, Pencoed, Wales

[9] Karolinska Inst, Unit Immunol & Allergy, Dept Med, Stockholm, Sweden

[10] PMU, Spinal Cord Injury & Tissue Regenerat Ctr Salzbur, Strubergasse 22, A-5020 Salzburg, Austria

[11] Salzburger Landeskliniken GesmbH SALK, Univ Hosp, Dept Blood Grp Serol & Transfus Med, Salzburg, Austria

[12] Capricor Therapeut, Los Angeles, CA USA

[13] Univ Utrecht, Dept Vasc Surg & Cardiol, Utrecht, Netherlands

[14] NUS Surg & A STAR, Singapore, Singapore

[15] Natl Tsing Hua Univ, Inst Biomed Engn, Hsinchu, Taiwan

[16] Gothenburg Univ, Sahlgrenska Acad, Inst Med, Krefting Res Ctr, Gothenburg, Sweden

[17] Codiak BioSci, Woburn, MA USA

[18] Univ Barcelona, Hosp Clin, ICREA ISGlobal Barcelona Inst Global Hlth, Barcelona, Spain

[19] Inst Invest Germans Trias & Pujol IGTP, Badalona, Spain

[20] Fed Off Safety Hlth Care, Vienna, Austria

[21] Austrian Agcy Hlth & Food Safety, Inst Surveillance, Vienna, Austria

[22] Univ Calif Irvine, Dept Pharmaceut Sci, Irvine, CA USA

[23] Univ Calif Irvine, Sue & Bill Gross Stem Cell Res Ctr, Irvine, CA USA

[24] Univ Queensland, Royal Brisbane & Womens Hosp, Ctr Clin Res, Brisbane, Qld, Australia

[25] Ochsner Clin Fdn, Dept Obstet & Gynecol, New Orleans, LA USA

[26] Hiroshima Univ, Inst Biomed & Hlth Sci, Dept Cellular & Mol Biol, Hiroshima, Japan

[27] Natl Univ Singapore, Fac Dent, Singapore, Singapore

[28] Univ Utrecht, Fac Vet Med, Dept Biochem & Cell Biol, Utrecht, Netherlands

[29] Tufts Univ, Cummings Sch Vet Med, Dept Clin Sci, North Grafton, MA USA

[30] Chinese Acad Sci, State Key Lab Resp Dis Guangzhou Inst Biomed & Hl, Guangzhou, Guangdong, Peoples R China

[31] ASTAR, Inst Med Biol, 8A Biomed Grove,05-505 Immunos, Singapore 138648, Singapore

[32] Univ Colorado, Dept Chem & Biochem, Campus Box 215, Boulder, CO 80309 USA

[33] Univ Colorado, BioFrontiers Inst, Boulder, CO 80309 USA

[34] Tsinghua Univ, Dept Chem, CBMS, Beijing, Peoples R China

[35] Univ Duisburg Essen, Univ Hosp Essen, Inst Transfus Med, Duisburg, Germany

来源：

STEM CELLS TRANSLATIONAL MEDICINE | 2017年 / 6卷 / 08期

关键词：

Stem cells; Cellular therapy; Clinical trials; Clinical translation; Extracellular vesicles; Therapeutics; Exosomes; Microvesicles;

D O I：

10.1002/sctm.17-0055

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Growing interest in extracellular vesicles (EVs, including exosomes and microvesicles) as therapeutic entities, particularly in stem cell-related approaches, has underlined the need for standardization and coordination of development efforts. Members of the International Society for Extracellular Vesicles and the Society for Clinical Research and Translation of Extracellular Vesicles Singapore convened a Workshop on this topic to discuss the opportunities and challenges associated with development of EV-based therapeutics at the preclinical and clinical levels. This review outlines topic-specific action items that, if addressed, will enhance the development of best-practice models for EV therapies.

引用

页码：1730 / 1739

页数：10

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