Overcoming the resistance to BRAF inhibitor by the double BRAF and MEK inhibitions in advanced melanoma: a case report

被引：4
作者：
Kattan, Joseph [1 ]
Kattan, Clarisse [1 ]
Farhat, Fadi [2 ]
Assi, Tarek [2 ,3 ]
机构：
[1] St Joseph Univ, Hotel Dieu France Univ Hosp, Hematol Oncol Dept, Fac Med, Beirut, Lebanon
[2] Hammoud Hosp UMC, Hematol Oncol Dept, Saida, Lebanon
[3] St Joseph Univ, Hematol Oncol Dept, Fac Med, Beirut, Lebanon
来源：
ANTI-CANCER DRUGS | 2019年 / 30卷 / 10期
关键词：
binimetinib; BRAF; encorafenib; immune checkpoint; MEK; melanoma; resistance; METASTATIC MELANOMA; MUTANT MELANOMA; OPEN-LABEL; NIVOLUMAB; COMBINATION; DABRAFENIB; TRAMETINIB; IPILIMUMAB; EFFICACY; STANDARD;
D O I：
10.1097/CAD.0000000000000827
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The advent of BRAF and MEK inhibitors changed the landscape of the management of BRAF mutated melanoma patients. In this article, we report the case of a 51-year-old man with BRAF mutated locally advanced cutaneous melanoma of the head who demonstrated a limited response to initial anti-BRAF monotherapy followed by extensive surgery. Anti-PD1 therapy failed to reverse the disease progression. However, subsequent double inhibition of the BRAF and MEK pathways induced a fast and remarkable tumour response.
引用
收藏
页码：1052 / 1054
页数：3
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