Evaluating the promise of inclusion of African ancestry populations in genomics

被引：103

作者：

Bentley, Amy R. ^{[1
]}

Callier, Shawneequa L. ^{[1
,2
]}

Rotimi, Charles N. ^{[1
]}

机构：

[1] NHGRI, Ctr Res Genom & Global Hlth, NIH, Bethesda, MD 20892 USA

[2] George Washington Univ, Sch Med & Hlth Sci, Dept Clin Res & Leadership, Washington, DC 20052 USA

来源：

NPJ GENOMIC MEDICINE | 2020年 / 5卷 / 01期

基金：

美国国家卫生研究院;

关键词：

SUB-SAHARAN AFRICA; PRECISION MEDICINE; GENETIC-VARIATION; COLLABORATIVE CENTER; GLOBAL POPULATIONS; EPIDEMIOLOGY PAGE; RISK PREDICTION; HUMAN HEREDITY; DISEASE; HEALTH;

D O I：

10.1038/s41525-019-0111-x

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The lack of representation of diverse ancestral backgrounds in genomic research is well-known, and the resultant scientific and ethical limitations are becoming increasingly appreciated. The paucity of data on individuals with African ancestry is especially noteworthy as Africa is the birthplace of modern humans and harbors the greatest genetic diversity. It is expected that greater representation of those with African ancestry in genomic research will bring novel insights into human biology, and lead to improvements in clinical care and improved understanding of health disparities. Now that major efforts have been undertaken to address this failing, is there evidence of these anticipated advances? Here, we evaluate the promise of including diverse individuals in genomic research in the context of recent literature on individuals of African ancestry. In addition, we discuss progress and achievements on related technological challenges and diversity among scientists conducting genomic research.

引用

页数：9

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