Synthesis and in vitro evaluation of the anticancer activity of novel fluorinated thiazolo[4,5-d]pyrimidines

被引：55
作者：
Fahmy, HTY
Rostom, SAF
Saudi, MN
Zjawiony, JK
Robins, DJ
机构：
[1] Univ Mississippi, Sch Pharm, Dept Pharmacognosy, University, MS 38677 USA
[2] Univ Alexandria, Fac Pharm, Dept Pharmaceut Chem, Alexandria, Egypt
[3] Univ Glasgow, Dept Chem, Glasgow G12 8QQ, Lanark, Scotland
来源：
ARCHIV DER PHARMAZIE | 2003年 / 336卷 / 4-5期
关键词：
thaizole; fluorinated; thiazolo[4,5-d]pyrimidines; anticancer activity;
D O I：
10.1002/ardp.200300734
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The synthesis of several thiazolo[4,5-d]pyrimidines containing a fluorophenyl moiety substituted at different positions and through different bridges is described. Twenty new compounds were prepared and evaluated for their anticancer activity using the USA-NCl in-vitro screening program. Three compounds were found active and their anticancer activity against 60 human tumor cell lines are described in detail.
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收藏
页码：216 / 225
页数：10
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