HLA-DR5 and DQB1(*)03 class II alleles are associated with cutaneous T-cell lymphoma

被引:83
作者
Jackow, CM
McHam, JB
Friss, A
Alvear, J
Reveille, JR
Duric, M
机构
[1] UNIV TEXAS,SCH MED,DEPT DERMATOL,HOUSTON,TX 77030
[2] UNIV TEXAS,SCH MED,DEPT INTERNAL MED,HOUSTON,TX 77030
[3] MD ANDERSON CANC CTR,DIV MED,DERMATOL SECT,HOUSTON,TX
关键词
mycosis fungoides; Sezary syndrome; HLA disease association; cancer;
D O I
10.1111/1523-1747.ep12363352
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Cutaneous T-cell lymphoma (CTCL) may present with eczematous lesions, mycosis fungoides (RIF), or as exfoliative erythroderma with circulating atypical cells, Sezary syndrome (SS), The ''malignant'' T cells are epidermotropic and clonal, but whether they respond to antigen stimulation is unknown, Because CD4+ lymphocytes recognize antigen presented by histocompatibility locus antigen (HLA) class II molecules, and HLA associations have been found in autoimmune skin diseases, we determined by allele-specific oligonucleotide typing whether HLA-DR or DQ alleles were associated with CTCL and its two variants MF (n = 47) and SS (n = 23), Phenotypic frequencies were compared by chi-square and Fisher exact test, and p values were corrected independently for either 12 DR or 15 DQ alleles, HLA-DR5, previously associated with ME, was significantly increased in all 70 CTCL patients (31.5%) versus controls (11%) (uncorrected p value [p(nc)] = 0.000038, odds ratio [OR] = 3.9, 1.9 < OR < 8.1), in MF patients (34%) (p(nc) = 0.000047, OR = 3.62, 1.9 < OR < 10), and in 55 patients (26%) (p(nc) = 0.03, OR = 3, 0.9 < OR < 9.3). HLA-DQB1*03 alleles (0301, 0302, and 0303) were increased in 72% of all CTCL patients versus 49% of controls (corrected p value [p(c)] = 0.014, OR = 2.7, 1.4 < OR < 5.1), in SS (82%) (p(c) = 0.05, OR = 4.7, 1.4 < OR < 5), and in MF (67%) (p(nc) = 0.024, OR = 2.15, 1 < OR < 4.5), DQB1*0502 was strongly increased in SS patients (p(c) = 0.045, OR = 7.75, 1.25 < OR < 48). Although HLA-DQB1*0603 and HLA-DR6 (1301, 1302, and 1402) were decreased in all groups, the decreases were not statistically significant. These data suggest that certain HLA-DRB and DQB1 alleles, also associated with other T-cell-mediated skin diseases, may participate in the pathogenesis of or susceptibility to CTCL.
引用
收藏
页码:373 / 376
页数:4
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