Synthesis, antioxidant properties and antiproliferative activities of tetrameric copper and copper-zinc metal complexes of catecholamine Schiff base ligand

被引：7

作者：

Dutta, S

Bendre, R

Padhye, S ^{[1
]}

Ahmed, F

Sarkar, F

机构：

[1] Wayne State Univ, Sch Med, Dept Biochem & Mol Biol, Detroit, MI 48201 USA

[2] Univ Pune, Dept Chem, Pune, Maharashtra, India

来源：

SYNTHESIS AND REACTIVITY IN INORGANIC METAL-ORGANIC AND NANO-METAL CHEMISTRY | 2005年 / 35卷 / 01期

关键词：

Schiff base complexes; copper tetramer; copper-zinc mixed-metal complex; SOD activity; antiproliferative activity;

D O I：

10.1081/SIM-200047494

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Modulation of the intrinsic oxidative stress in invasive metastatic cancer cells using two superoxide dismutase mimicking conjugates of catecholamine Schiff base ligand 3-[(2' -(2" pyridylethyl) iminoethyl] benzene- 1,2 diol] ( 1) results in superior killing of malignant cells. The homometallic copper compound as well as its heterometallic copper- zinc counterpart ( 3) are characterized by spectroscopic, electrochemical and magnetic susceptibility measurements where the latter shows remarkable SOD activity ( IC50 = 0.94 mu M) as well as a potent antiproliferative activity against estrogen independent breast ( BT- 20) and androgen independent prostate cancer ( PC- 3) cell lines.

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页码：3 / 10

页数：8

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