An efficient, multicomponent approach for solvent-free synthesis of 2-amino-4H-chromene scaffold

被引:91
作者
Naimi-Jamal, M. Reza [1 ]
Mashkouri, Sara [1 ]
Sharifi, Ali [2 ]
机构
[1] Iran Univ Sci & Technol, Res Lab Green Organ Synth, Dept Chem, Tehran 16846, Iran
[2] Chem & Chem Engn Res Ctr Iran, Tehran, Iran
关键词
2-Amino-4H-chromenes; Solvent-free; Multicomponent reactions; Domino reactions; Knoevenagel-Michael addition; POT 3-COMPONENT CONDENSATION; THROUGHPUT SCREENING ASSAY; AQUA MEDIATED SYNTHESIS; SUBSTITUTED; 2-AMINO-4H-CHROMENES; HETEROCYCLIC SYNTHESIS; TERMINAL ALKYNES; GREEN SYNTHESIS; 2-AMINO-2-CHROMENES; DERIVATIVES; CATALYST;
D O I
10.1007/s11030-010-9246-5
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Solvent-free one-pot synthesis of 2-amino-4H-chromene scaffold is described in a very simple, efficient, and environmentally benign method using sodium carbonate as a cheap and non-toxic catalyst with up to excellent yields.
引用
收藏
页码:473 / 477
页数:5
相关论文
共 37 条
[21]   Nanosized magnesium oxide as catalyst for the rapid and green synthesis of substituted 2-amino-2-chromenes [J].
Kumar, Dalip ;
Reddy, V. Buchi ;
Mishra, Braj G. ;
Rana, R. K. ;
Nadagouda, Mallikarjuna N. ;
Varma, Rajender S. .
TETRAHEDRON, 2007, 63 (15) :3093-3097
[22]   Basic alumina catalysed synthesis of substituted 2-amino-2-chromenes via three-component reaction [J].
Maggi, R ;
Ballini, R ;
Sartori, G ;
Sartorio, R .
TETRAHEDRON LETTERS, 2004, 45 (11) :2297-2299
[23]   Mechanochemical Solvent-Free and Catalyst-Free One-Pot Synthesis of Pyrano[2,3-d]Pyrimidine-2,4(1H,3H)-Diones with Quantitative Yields [J].
Mashkouri, Sara ;
Naimi-Jamal, M. Reza .
MOLECULES, 2009, 14 (01) :474-479
[24]  
MOHR SJ, 1975, CANCER RES, V35, P3750
[25]   One-pot solvent-free preparation of 2-phenyl-1,3,2-aryldioxaborins on acidic alumina [J].
Naimi-Jamal, M. Reza ;
Mirzaei, Mojtaba ;
Bolourtchian, M. ;
Sharifi, Ali .
SYNTHETIC COMMUNICATIONS, 2006, 36 (18) :2711-2717
[26]   The current status of heterocyclic combinatorial libraries [J].
Nefzi, A ;
Ostresh, JM ;
Houghten, RA .
CHEMICAL REVIEWS, 1997, 97 (02) :449-472
[27]   2(3H)-benzoxazolone and bioisosters as "Privileged Scaffold" in the design of pharmacological probes [J].
Poupaert, J ;
Carato, P ;
Colacillo, E ;
Yous, S .
CURRENT MEDICINAL CHEMISTRY, 2005, 12 (07) :877-885
[28]   Convenient and efficient method for synthesis of substituted 2-amino-2-chromenes using catalytic amount of iodine and K2CO3 in aqueous medium [J].
Ren, Yi-Ming ;
Cai, Chun .
CATALYSIS COMMUNICATIONS, 2008, 9 (06) :1017-1020
[29]   Modified Glaser reaction of terminal alkynes on KF/alumina [J].
Sharifi, A ;
Mirzaei, M ;
Naimi-Jamal, MR .
MONATSHEFTE FUR CHEMIE, 2006, 137 (02) :213-217
[30]   Microwave assisted Mannich reaction of terminal alkynes on alumina [J].
Sharifi, A ;
Farhangian, H ;
Mohsenzadeh, F ;
Naimi-Jamal, MR .
MONATSHEFTE FUR CHEMIE, 2002, 133 (02) :199-204