Treatment of childhood acute lymphoblastic leukemia in Iraq: a 17-year experience from a single center

被引：2

作者：

Al-Hadad, Salma Abbas ^{[1
]}

Al-Jadiry, Mazin Faisal ^{[1
]}

Ghali, Hasanein Habeeb ^{[1
]}

Al-Badri, Safaa A. Faraj ^{[1
]}

Al-Saeed, Raghad Majid ^{[2
]}

Al-Darraji, Amir Fadhil ^{[2
]}

Sabhan, Ahmed Hatem ^{[2
]}

Fadhil, Samaher Abdulrazzaq ^{[2
]}

Hussein, Hanadi Munaf ^{[2
]}

Abed, Wisam Majeed ^{[3
]}

Ameen, Najiha Ahmed ^{[3
]}

Sahan, Jawad Kadhum Abid ^{[2
]}

Jaafar, Ghufran Qassim ^{[2
]}

Abed, Aseel Rashid ^{[2
]}

Mohamed, Sara ^{[4
]}

Moleti, Maria Luisa ^{[4
]}

Piciocchi, Alfonso ^{[5
]}

Foa, Robin ^{[4
]}

Testi, Anna Maria ^{[4
]}

机构：

[1] Univ Baghdad, Children Welf Teaching Hosp Med City, Coll Med, Dept Pediat,Oncol Unit, Baghdad, Iraq

[2] Children Welf Teaching Hosp Med City, Oncol Unit, Baghdad, Iraq

[3] Children Welf Teaching Hosp Med City, Hematol Lab Dept, Baghdad, Iraq

[4] Sapienza Univ, Dept Translat & Precis Med, Hematol, Via Benevento 6, I-00161 Rome, Italy

[5] GIMEMA Fdn, GIMEMA Data Ctr, Rome, Italy

来源：

LEUKEMIA & LYMPHOMA | 2021年 / 62卷 / 14期

关键词：

Acute lymphoblastic leukemia; children; low-income country; telemedicine; PEDIATRIC ONCOLOGY; INCOME COUNTRIES; INTERNATIONAL INCIDENCE; CHILDREN; IMPACT; CANCER; CURE; IMPLEMENTATION; MANAGEMENT; RISK;

D O I：

10.1080/10428194.2021.1961237

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We performed a retrospective analysis of 1415 acute lymphoblastic leukemia children diagnosed between January 2000 and December 2016 at Children Welfare Teaching Hospital, Baghdad, Iraq. Patients were divided into three cohorts according to treatment period (2000-2005; 2006-2011; 2012-2016). Treatments were based on modified-UKALL protocols; a steroid-pre-phase was introduced from September 2008. The overall complete remission was 86%, increased from 80% to 91% in the last period. Early deaths occurred in 10%, decreasing to 6%, overtime. Relapses were 23%; toxic deaths and abandonment 8% and 13%, respectively. At a median follow-up of 65.3 months, with abandonment considered as an event, the 5-year overall survival (OS) and event-free survival were 62.2% and 46.3%, statistically influenced by treatment period (5-year OS 62.6%, 59.1%, 66.3%; p=.057, respectively). Though pediatric ALL survival in Iraq is still below that observed in high income countries, survival rates progressively improved. Toxic deaths remain an important cause of failure.

引用

页码：3430 / 3439

页数：10

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