The global antigenic diversity of swine influenza A viruses

被引：134

作者：

Lewis, Nicola S. ^{[1
]}

Russell, Colin A. ^{[2
]}

Langat, Pinky ^{[3
]}

Anderson, Tavis K. ^{[4
]}

Berger, Kathryn ^{[2
]}

Bielejec, Filip ^{[5
]}

Burke, David F. ^{[1
]}

Dudas, Gytis ^{[6
]}

Fonville, Judith M. ^{[1
]}

Fouchier, Ron A. M. ^{[6
]}

Kellam, Paul ^{[3
]}

Koel, Bjorn F. ^{[7
,17
]}

Lemey, Philippe ^{[5
]}

Tung Nguyen ^{[8
]}

Nuansrichy, Bundit ^{[9
]}

Peiris, J. S. Malik ^{[10
]}

Saito, Takehiko ^{[11
]}

Simon, Gaelle ^{[12
]}

Skepner, Eugene ^{[1
]}

Takemae, Nobuhiro ^{[11
]}

Webby, Richard J. ^{[13
]}

Van Reeth, Kristien ^{[14
]}

Brookes, Sharon M. ^{[15
]}

Larsen, Lars ^{[16
]}

Watson, Simon J. ^{[3
]}

Brown, Ian H. ^{[15
]}

Vincent, Amy L. ^{[4
]}

机构：

[1] Univ Cambridge, Dept Zool, Cambridge, England

[2] Univ Cambridge, Dept Vet Med, Cambridge, England

[3] Wellcome Trust Sanger Inst, Hinxton, England

[4] USDA ARS, Virus & Pr Res Unit, Natl Anim Dis Ctr, Ames, IA USA

[5] Katholieke Univ Leuven, Rega Inst Med Res, Dept Microbiol & Immunol, Clin & Epidemiol Virol, Leuven, Belgium

[6] Univ Edinburgh, Inst Evolutionary Biol, Edinburgh, Midlothian, Scotland

[7] Erasmus MC, Dept Virosci, Rotterdam, Netherlands

[8] Natl Ctr Vet Diagnost, Dept Anim Hlth, Hanoi, Vietnam

[9] Natl Inst Anim Hlth, Bangkok, Thailand

[10] Univ Hong Kong, Sch Publ Hlth, Hong Kong, Hong Kong, Peoples R China

[11] Natl Inst Anim Hlth, Ibaraki, Japan

[12] Anses, Ploufragan Plouzane Lab, Swine Virol Immunol Unit, Ploufragan, France

[13] St Jude Childrens Res Hosp, 332 N Lauderdale St, Memphis, TN 38105 USA

[14] Univ Ghent, Fac Vet Med, Virol Lab, B-9000 Ghent, Belgium

[15] Anim Hlth & Plant Agcy, Weybridge, Surrey, England

[16] Tech Univ Denmark, Natl Vet Inst, Frederiksberg, Denmark

[17] Univ Amsterdam, Acad Med Ctr, Dept Med Microbiol, NL-1105 AZ Amsterdam, Netherlands

来源：

ELIFE | 2016年 / 5卷

基金：

英国医学研究理事会; 美国农业部;

关键词：

PANDEMIC H1N1 INFLUENZA; BINDING SITE DETERMINE; EURASIAN AVIAN-LIKE; UNITED-STATES; GENETIC EVOLUTION; A(H1N1)PDM09 VIRUS; EUROPEAN SWINE; H3N2; VIRUSES; HUMAN-ORIGIN; US SWINE;

D O I：

10.7554/eLife.12217

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Swine influenza presents a substantial disease burden for pig populations worldwide and poses a potential pandemic threat to humans. There is considerable diversity in both H1 and H3 influenza viruses circulating in swine due to the frequent introductions of viruses from humans and birds coupled with geographic segregation of global swine populations. Much of this diversity is characterized genetically but the antigenic diversity of these viruses is poorly understood. Critically, the antigenic diversity shapes the risk profile of swine influenza viruses in terms of their epizootic and pandemic potential. Here, using the most comprehensive set of swine influenza virus antigenic data compiled to date, we quantify the antigenic diversity of swine influenza viruses on a multi-continental scale. The substantial antigenic diversity of recently circulating viruses in different parts of the world adds complexity to the risk profiles for the movement of swine and the potential for swine-derived infections in humans.

引用

页数：17

共 73 条

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