The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease

被引：424

作者：

Cookson, Mark R. ^{[1
]}

机构：

[1] NIA, Neurogenet Lab, NIH, Bethesda, MD 20982 USA

来源：

NATURE REVIEWS NEUROSCIENCE | 2010年 / 11卷 / 12期

基金：

美国国家卫生研究院;

关键词：

AUTOSOMAL-DOMINANT PARKINSONISM; ALPHA-SYNUCLEIN; LEUCINE-RICH-REPEAT-KINASE-2; LRRK2; CYTOPLASMIC LOCALIZATION; 14-3-3; BINDING; ROC DOMAIN; MUTATIONS; PROTEIN; PHOSPHORYLATION; GENE;

D O I：

10.1038/nrn2935

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Parkinson's disease, like many common age-related conditions, is now recognized to have a substantial genetic component. Here, I discuss how mutations in a large complex gene-leucine-rich repeat kinase 2 (LRRK2) - affect protein function, and I review recent evidence that LRRK2 mutations affect pathways that involve other proteins that have been implicated in Parkinson's disease, specifically a-synuclein and tau. These concepts can be used to understand disease processes and to develop therapeutic opportunities for the treatment of Parkinson's disease.

引用

页码：791 / 797

页数：7

共 50 条

[41] Leucine-rich repeat kinase-2 (LRRK2) modulates microglial phenotype and dopaminergic neurodegeneration
Dwyer, Zach
Rudyk, Chris
Thompson, Ashley
Farmer, Kyle
Fenner, Barbara
Fortin, Teresa
Derksen, Alexa
Sun, Hongyu
Hayley, Shawn
NEUROBIOLOGY OF AGING, 2020, 91 : 45 - 55
[42] Leucine-rich repeat kinase 2 at a glance
Zhu, Christiane
Herbst, Susanne
Lewis, Patrick A.
JOURNAL OF CELL SCIENCE, 2023, 136 (17)
[43] The Development and Design Strategy of Leucine-Rich Repeat Kinase 2 Inhibitors: Promising Therapeutic Agents for Parkinson's Disease
Tang, Xu
Xing, Shuaishuai
Ma, Mingkang
Xu, Ziwei
Guan, Qianwen
Chen, Yuting
Feng, Feng
Liu, Wenyuan
Chen, Tingkai
Chen, Yao
Sun, Haopeng
JOURNAL OF MEDICINAL CHEMISTRY, 2023, 66 (04) : 2282 - 2307
[44] Loss of Leucine-Rich Repeat Kinase 2 (LRRK2) in Rats Leads to Progressive Abnormal Phenotypes in Peripheral Organs
Baptista, Marco A. S.
Dave, Kuldip D.
Frasier, Mark A.
Sherer, Todd B.
Greeley, Melanie
Beck, Melissa J.
Varsho, Julie S.
Parker, George A.
Moore, Cindy
Churchill, Madeline J.
Meshul, Charles K.
Fiske, Brian K.
PLOS ONE, 2013, 8 (11):
[45] Investigation of leucine-rich repeat kinase 2
Anand, Vasanti S.
Reichling, Laurie J.
Lipinski, Kerri
Stochaj, Wayne
Duan, Weili
Kelleher, Kerry
Pungaliya, Pooja
Brown, Eugene L.
Reinhart, Peter H.
Somberg, Richard
Hirst, Warren D.
Riddle, Steven M.
Braithwaite, Steven P.
FEBS JOURNAL, 2009, 276 (02) : 466 - 478
[46] Leucine-Rich Repeat Kinase 2 (LRRK2) Cellular Biology: A Review of Recent Advances in Identifying Physiological Substrates and Cellular Functions
Drolet, Robert E.
Sanders, John M.
Kern, Jonathan T.
JOURNAL OF NEUROGENETICS, 2011, 25 (04) : 140 - 151
[47] Development of a mechanism-based high-throughput screen assay for leucine-rich repeat kinase 2-Discovery of LRRK2 inhibitors
Liu, Min
Poulose, Shibu
Schuman, Eli
Zaitsev, Alexandra D.
Dobson, Brittany
Auerbach, Ken
Seyb, Kathleen
Cuny, Gregory D.
Glicksman, Marcie A.
Stein, Ross L.
Yue, Zhenyu
ANALYTICAL BIOCHEMISTRY, 2010, 404 (02) : 186 - 192
[48] The Double-Faceted Role of Leucine-Rich Repeat Kinase 2 in the Immunopathogenesis of Parkinson's Disease
Zhang, Mengfei
Li, Chaoyi
Ren, Jie
Wang, Huakun
Yi, Fang
Wu, Junjiao
Tang, Yu
FRONTIERS IN AGING NEUROSCIENCE, 2022, 14
[49] Vacuolar protein sorting 35 (Vps35) rescues locomotor deficits and shortened lifespan in Drosophila expressing a Parkinson's disease mutant of Leucine-rich repeat kinase 2 (LRRK2)
Linhart, Radek
Wong, Sarah Anne
Cao, Jieyun
Tran, Melody
Ardrey, Casey
Huynh, Anne
Park, Jong Min
Hsu, Christine
Taha, Saher
Peterson, Rentia
Shea, Shannon
Kurian, Jason
Venderova, Katerina
MOLECULAR NEURODEGENERATION, 2014, 9
[50] The leucine rich repeat kinase 2 (LRRK2) G2019S substitution mutation
Hassin-Baer, Sharon
Laitman, Yael
Azizi, Esther
Molchadski, Irena
Galore-Haskel, Gilli
Barak, Frida
Cohen, Oren S.
Friedman, Eitan
JOURNAL OF NEUROLOGY, 2009, 256 (03) : 483 - 487

← 1 2 3 4 5 →