The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease

被引：431

作者：

Cookson, Mark R. ^{[1
]}

机构：

[1] NIA, Neurogenet Lab, NIH, Bethesda, MD 20982 USA

来源：

NATURE REVIEWS NEUROSCIENCE | 2010年 / 11卷 / 12期

基金：

美国国家卫生研究院;

关键词：

AUTOSOMAL-DOMINANT PARKINSONISM; ALPHA-SYNUCLEIN; LEUCINE-RICH-REPEAT-KINASE-2; LRRK2; CYTOPLASMIC LOCALIZATION; 14-3-3; BINDING; ROC DOMAIN; MUTATIONS; PROTEIN; PHOSPHORYLATION; GENE;

D O I：

10.1038/nrn2935

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Parkinson's disease, like many common age-related conditions, is now recognized to have a substantial genetic component. Here, I discuss how mutations in a large complex gene-leucine-rich repeat kinase 2 (LRRK2) - affect protein function, and I review recent evidence that LRRK2 mutations affect pathways that involve other proteins that have been implicated in Parkinson's disease, specifically a-synuclein and tau. These concepts can be used to understand disease processes and to develop therapeutic opportunities for the treatment of Parkinson's disease.

引用

页码：791 / 797

页数：7

共 74 条

[71] Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of α-synuclein, and apoptotic cell death in aged mice [J].