Nanoscale shear deformation mechanisms of opposing cartilage aggrecan macromolecules

被引：24
作者：
Han, Lin
Dean, Delphine
Mao, Pan
Ortiz, Christine
Grodzinsky, Alan J. [1 ]
机构：
[1] MIT, Dept Mat Sci & Engn, Cambridge, MA 02139 USA
[2] MIT, Dept Elect Engn & Comp Sci, Cambridge, MA 02139 USA
[3] MIT, Dept Engn Mech, Cambridge, MA 02139 USA
[4] MIT, Dept Biol Engn, Cambridge, MA 02139 USA
来源：
BIOPHYSICAL JOURNAL | 2007年 / 93卷 / 05期
关键词：
D O I：
10.1529/biophysj.107.114025
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
The nanoscale shear deformation behavior of two opposing end-grafted aggrecan layers was studied in aqueous solutions using atomic force microscopy, and was observed to depend markedly on bath ionic strength, the presence of calcium ions, and the applied lateral displacement rate. These results provide molecular-level insights into the contribution of aggrecan deformation mechanisms to cartilage tissue-level material properties.
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收藏
页码：L23 / L25
页数：3
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