Nanoscale shear deformation mechanisms of opposing cartilage aggrecan macromolecules

被引:24
作者
Han, Lin
Dean, Delphine
Mao, Pan
Ortiz, Christine
Grodzinsky, Alan J. [1 ]
机构
[1] MIT, Dept Mat Sci & Engn, Cambridge, MA 02139 USA
[2] MIT, Dept Elect Engn & Comp Sci, Cambridge, MA 02139 USA
[3] MIT, Dept Engn Mech, Cambridge, MA 02139 USA
[4] MIT, Dept Biol Engn, Cambridge, MA 02139 USA
关键词
D O I
10.1529/biophysj.107.114025
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
The nanoscale shear deformation behavior of two opposing end-grafted aggrecan layers was studied in aqueous solutions using atomic force microscopy, and was observed to depend markedly on bath ionic strength, the presence of calcium ions, and the applied lateral displacement rate. These results provide molecular-level insights into the contribution of aggrecan deformation mechanisms to cartilage tissue-level material properties.
引用
收藏
页码:L23 / L25
页数:3
相关论文
共 13 条
[1]   Nanoscale conformation and compressibility of cartilage aggrecan using microcontact printing and atomic force microscopy [J].
Dean, D ;
Han, L ;
Ortiz, C ;
Grodzinsky, AJ .
MACROMOLECULES, 2005, 38 (10) :4047-4049
[2]   Compressive nanomechanics of opposing aggrecan macromolecules [J].
Dean, Delphine ;
Han, Lin ;
Grodzinsky, Alan J. ;
Ortiz, Christine .
JOURNAL OF BIOMECHANICS, 2006, 39 (14) :2555-2565
[3]   The osmotic pressure of chondroitin sulphate solutions: Experimental measurements and theoretical analysis [J].
Ehrlich, S ;
Wolff, N ;
Schneiderman, R ;
Maroudas, A ;
Parker, KH ;
Winlove, CP .
BIORHEOLOGY, 1998, 35 (06) :383-397
[4]   THE SIGNIFICANCE OF ELECTRO-MECHANICAL AND OSMOTIC FORCES IN THE NON-EQUILIBRIUM SWELLING BEHAVIOR OF ARTICULAR-CARTILAGE IN TENSION [J].
GRODZINSKY, AJ ;
ROTH, V ;
MYERS, E ;
GROSSMAN, WD ;
MOW, VC .
JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 1981, 103 (04) :221-231
[5]  
HAN L, 2006, BIOMOLECULAR ADHESIO, V361
[6]   Lateral nanomechanics of cartilage aggrecan macromolecules [J].
Han, Lin ;
Dean, Delphine ;
Ortiz, Christine ;
Grodzinsky, Alan J. .
BIOPHYSICAL JOURNAL, 2007, 92 (04) :1384-1398
[7]   PROTEOGLYCANS - MANY FORMS AND MANY FUNCTIONS [J].
HARDINGHAM, TE ;
FOSANG, AJ .
FASEB JOURNAL, 1992, 6 (03) :861-870
[8]   BINDING OF CALCIUM TO GLYCOSAMINOGLYCANS - AN EQUILIBRIUM DIALYSIS STUDY [J].
HUNTER, GK ;
WONG, KS ;
KIM, JJ .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1988, 260 (01) :161-167
[9]   INTERACTION OF PROTEOGLYCANS AND CHONDROITIN SULFATES WITH CALCIUM OR PHOSPHATE IONS [J].
MACGREGOR, EA ;
BOWNESS, JM .
CANADIAN JOURNAL OF BIOCHEMISTRY, 1971, 49 (04) :417-+
[10]  
Maroudas A., 1979, ADULT ARTICULAR CART, V2nd, P215