The Aggregation of Aβ42 Induced by Nano Copper and the Antagonistic Action of Polysaccharides

被引：3
作者：
Wang, Wei [1 ]
Zhang, Guoguang [1 ]
Zou, Jinmei [1 ]
机构：
[1] Minnan Normal Univ, Dept Biol Sci & BioTechnol, Zhangzhou 363000, Peoples R China
来源：
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY | 2015年 / 175卷 / 03期
关键词：
A beta(42); Aggregation; Copper nanoparticle; Polysaccharide; THIOFLAVIN-T; NANOPARTICLES; BINDING;
D O I：
10.1007/s12010-014-1385-1
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The toxic effect of A beta(42) induced by copper nanoparticle (Cu NPs) was studied by atomic force microscopy (AFM), circular dichroism (CD) spectroscopy, and Thioflavin T (ThT) fluorescence technique. Five hundred nanometers of copper nanoparticle capped with polyvinylpyrrolidone (PVP) was used to evaluate the aggregation and fibrils of A beta(42). The morphologies of A beta(42) incubated in the presence of Cu NPs changed gradually. The aggregation and fibrils were observed in AFM images. However, in the presence of polysaccharides, the Cu NPs-induced fibrillation of A beta(42) was inhibited. Interestingly, the formed Cu NPs-polysaccharides complexes can even remodel the preformed A beta(42) fibrils into the low neurotoxic amorphous aggregates, which were maybe ascribed to the higher affinity of polysaccharides for A beta(42) than Cu NPs. Besides, it was found that the binding constant of Cu NPs to A beta(42) is smaller than that of polysaccharides. The relationship among polysaccharides, copper nanoparticle, and A beta(42) morphologies and its neurotoxicity were discussed, and the binding force was analyzed.
引用
收藏
页码：1557 / 1566
页数：10
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