Hope for a broken heart?

被引：10
作者：
Leinwand, LA [1 ]
机构：
[1] Univ Colorado, Dept Mol Cell & Dev Biol, Boulder, CO 80309 USA
来源：
CELL | 2003年 / 114卷 / 06期
关键词：
D O I：
10.1016/S0092-8674(03)00718-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Heated debate has surrounded the issue of whether adult stem cells can differentiate into cardiac myocytes and contribute to the function of the heart. In this issue of Cell, Beltrami et al. (2003) demonstrate stem cells in the adult rat heart that differentiate into cardiac myocytes in vitro and, when injected into the adult rat heart, can reconstitute the injured myocardium and improve function. These findings should weigh heavily in future debates about the existence of stem cells in the adult heart and their capacity for functional repair after injury.
引用
收藏
页码：658 / 659
页数：2
相关论文
共 11 条
  • [1] Adult cardiac stem cells are multipotent and support myocardial regeneration
    Beltrami, AP
    Barlucchi, L
    Torella, D
    Baker, M
    Limana, F
    Chimenti, S
    Kasahara, H
    Rota, M
    Musso, E
    Urbanek, K
    Leri, A
    Kajstura, J
    Nadal-Ginard, B
    Anversa, P
    [J]. CELL, 2003, 114 (06) : 763 - 776
  • [2] Smooth muscle cells, but not myocytes, of host origin in transplanted human hearts
    Glaser, R
    Lu, MM
    Narula, N
    Epstein, JA
    [J]. CIRCULATION, 2002, 106 (01) : 17 - 19
  • [3] Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells
    Jackson, KA
    Majka, SM
    Wang, HG
    Pocius, J
    Hartley, CJ
    Majesky, MW
    Entman, ML
    Michael, LH
    Hirschi, KK
    Goodell, MA
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2001, 107 (11) : 1395 - 1402
  • [4] Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell
    Krause, DS
    Theise, ND
    Collector, MI
    Henegariu, O
    Hwang, S
    Gardner, R
    Neutzel, S
    Sharkis, SJ
    [J]. CELL, 2001, 105 (03) : 369 - 377
  • [5] Evidence for cardiomyocyte repopulation by extracardiac progenitors in transplanted human hearts
    Laflamme, MA
    Myerson, D
    Saffitz, JE
    Murry, CE
    [J]. CIRCULATION RESEARCH, 2002, 90 (06) : 634 - 640
  • [6] Heart regeneration in adult MRL mice
    Leferovich, JM
    Bedelbaeva, K
    Samulewicz, S
    Zhang, XM
    Zwas, D
    Lankford, EB
    Heber-Katz, E
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (17) : 9830 - 9835
  • [7] Cardiomyocytes of noncardiac origin in myocardial biopsies of human transplanted hearts
    Müller, P
    Pfeiffer, P
    Koglin, J
    Schäfers, HJ
    Seeland, U
    Janzen, I
    Urbschat, S
    Böhm, M
    [J]. CIRCULATION, 2002, 106 (01) : 31 - 35
  • [8] Differentiation of human embryonic stem cells to cardiomyocytes - Role of coculture with visceral endoderm-like cells
    Mummery, C
    Ward-van Oostwaard, D
    Doevendans, P
    Spijker, R
    van den Brink, S
    Hassink, R
    van der Heyden, M
    Opthof, T
    Pera, M
    de la Riviere, AB
    Passier, R
    Tertoolen, L
    [J]. CIRCULATION, 2003, 107 (21) : 2733 - 2740
  • [9] Mobilized bone marrow cells repair the infarcted heart, improving function and survival
    Orlic, D
    Kajstura, J
    Chimenti, S
    Limana, F
    Jakoniuk, I
    Quaini, F
    Nadal-Ginard, B
    Bodine, DM
    Leri, A
    Anversa, P
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (18) : 10344 - 10349
  • [10] Bone marrow cells regenerate infarcted myocardium
    Orlic, D
    Kajstura, J
    Chimenti, S
    Jakoniuk, I
    Anderson, SM
    Li, BS
    Pickel, J
    McKay, R
    Nadal-Ginard, B
    Bodine, DM
    Leri, A
    Anversa, P
    [J]. NATURE, 2001, 410 (6829) : 701 - 705
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