The Multifaceted Role of Long Non-Coding RNA in Gastric Cancer: Current Status and Future Perspectives

被引：30

作者：

Li, Yifan ^{[1
,2
]}

Lu, Lan ^{[3
]}

Wu, Xu ^{[1
,2
]}

Li, Qianxiu ^{[1
]}

Zhao, Yueshui ^{[1
,2
]}

Du, Fukuan ^{[1
,2
]}

Chen, Yu ^{[1
,2
]}

Shen, Jing ^{[1
,2
]}

Xiao, Zhangang ^{[1
,2
]}

Wu, Zhigui ^{[1
,2
,4
]}

Hu, Wei ^{[5
]}

Cho, Chi Hin ^{[1
,2
]}

Li, Mingxing ^{[1
,2
]}

机构：

[1] Southwest Med Univ, Sch Pharm, Dept Pharmacol, Lab Mol Pharmacol, Luzhou 646000, Sichuan, Peoples R China

[2] South Sichuan Inst Translat Med, Luzhou 646000, Sichuan, Peoples R China

[3] Chengdu Univ, Sch Pharm, Sichuan Ind Inst Antibiot, Antibiot Res & Re Evaluat Key Lab Sichuan Prov, Chengdu 610106, Sichuan, Peoples R China

[4] Southwest Med Univ, Affiliated Hosp, Dept Pharm, Luzhou 646000, Sichuan, Peoples R China

[5] Southern Med Univ, Shenzhen Hosp, Dept Gastroenterol, Guangzhou 518000, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES | 2021年 / 17卷 / 11期

基金：

中国国家自然科学基金;

关键词：

long non-coding RNA; gastric cancer; drug resistance; helicobacter pylori; tumor microenvironment; PROMOTES CISPLATIN RESISTANCE; HELICOBACTER-PYLORI INFECTION; REGULATORY T-CELLS; CHEMOTHERAPY RESISTANCE; MULTIDRUG-RESISTANCE; SIGNALING PATHWAY; MEDIATED TRANSFER; FEEDBACK LOOP; PROLIFERATION; PROGRESSION;

D O I：

10.7150/ijbs.61410

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Gastric cancer (GC) is one of the major public health concerns. Long non-coding RNAs (lncRNAs) have been increasingly demonstrated to possess a strong correlation with GC and play a critical role in GC occurrence, progression, metastasis and drug resistance. Many studies have shed light on the understanding of the underlying mechanisms of lncRNAs in GC. In this review, we summarized the updated research about lncRNAs in GC, focusing on their roles in Helicobacter pylori infection, GC metastasis, tumor microenvironment regulation, drug resistance and associated signaling pathways. LncRNAs may serve as novel biomarkers for diagnosis and prognosis of GC and potential therapeutic targets. The research gaps and future directions were also discussed.

引用

页码：2737 / 2755

页数：19

共 146 条

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