Key concepts in MR spectroscopy and practical approaches to gaining biochemical information in children

被引:15
作者
Astrakas, Loukas G. [1 ]
Argyropoulou, Maria I. [2 ]
机构
[1] Univ Ioannina, Sch Med, Med Phys, POB 1186, GR-45110 Ioannina, Greece
[2] Univ Ioannina, Sch Med, Radiol, GR-45110 Ioannina, Greece
关键词
Magnetic resonance spectroscopy; Chemical shift; J-coupling; Metabolites; Central nervous system; Children; MAGNETIC-RESONANCE SPECTROSCOPY; PEDIATRIC BRAIN-TUMORS; METABOLITE CONCENTRATIONS; PROTON SPECTROSCOPY; TIME; NMR; QUANTITATION; LACTATE; QUANTIFICATION; DIAGNOSIS;
D O I
10.1007/s00247-014-3204-9
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Magnetic resonance spectroscopy (MRS) provides independent biochemical information and has become an invaluable adjunct to MRI and other imaging modalities. This review introduces key concepts and presents basic methodological steps regarding the acquisition and the interpretation of proton MRS. We review major brain metabolites and discuss MRS dependence on age, location, echo time and field strength.
引用
收藏
页码:941 / 951
页数:11
相关论文
共 65 条
[1]  
Adibhatla RM, 2006, AAPS J, V8, pE314
[2]  
Alger Jeffry R, 2010, Top Magn Reson Imaging, V21, P115, DOI 10.1097/RMR.0b013e31821e568f
[3]   GLUTAMATE-INDUCED NEURONAL DEATH - A SUCCESSION OF NECROSIS OR APOPTOSIS DEPENDING ON MITOCHONDRIAL-FUNCTION [J].
ANKARCRONA, M ;
DYPBUKT, JM ;
BONFOCO, E ;
ZHIVOTOVSKY, B ;
ORRENIUS, S ;
LIPTON, SA ;
NICOTERA, P .
NEURON, 1995, 15 (04) :961-973
[4]   Proton spectroscopy detected myoinositol in children with traumatic brain injury [J].
Ashwal, S ;
Holshouser, B ;
Tong, K ;
Serna, T ;
Osterdock, R ;
Gross, M ;
Kido, D .
PEDIATRIC RESEARCH, 2004, 56 (04) :630-638
[5]  
Ashwal S, 2014, J CHILD NEUROL
[6]   Noninvasive magnetic resonance spectroscopic imaging biomarkers to predict the clinical grade of pediatric brain tumors [J].
Astrakas, LG ;
Zurakowski, D ;
Tzika, AA ;
Zarifi, MK ;
Anthony, DC ;
De Girolami, U ;
Tarbell, NJ ;
Black, PM .
CLINICAL CANCER RESEARCH, 2004, 10 (24) :8220-8228
[7]   Brain damage results in down-regulation of N-acetylaspartate as a neuronal osmolyte [J].
Baslow, MH ;
Sucko, RF ;
Gaynor, K ;
Bhako, KK ;
Marks, N ;
Saito, M ;
Saito, M ;
Duff, K ;
Matsuoka, Y ;
Berg, MJ .
NEUROMOLECULAR MEDICINE, 2003, 3 (02) :95-103
[8]  
Boesch Chris, 1999, Molecular Aspects of Medicine, V20, P185, DOI 10.1016/S0098-2997(99)00007-2
[9]   NMR CHEMICAL-SHIFT IMAGING IN 3 DIMENSIONS [J].
BROWN, TR ;
KINCAID, BM ;
UGURBIL, K .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1982, 79 (11) :3523-3526
[10]   Potential of MR spectroscopy for assessment of glioma grading [J].
Bulik, Martin ;
Jancalek, Radim ;
Vanicek, Jiri ;
Skoch, Antonin ;
Mechl, Marek .
CLINICAL NEUROLOGY AND NEUROSURGERY, 2013, 115 (02) :146-153