mCPBA oxidation of acetyllycoctonine and its new products

被引：11

作者：

Shen, XL ^{[1
]}

Wang, FP ^{[1
]}

机构：

[1] Sichuan Univ, W China Coll Pharm, Dept Chem Med Nat Prod, Chengdu 610041, Peoples R China

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2005年 / 53卷 / 03期

关键词：

C-19-diterpenoid alkaloid; acetyllycoctonine; oxidation involving nitrogen atom; N-oxidation;

D O I：

10.1248/cpb.53.267

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Treatment of a lycoctonine-type alkaloid acetyllycoctonine (4) with mCPBA at room temperature led to acetyllycoctonine N-oxide (5) as the major product together with other interesting compounds 6-12 as the minor products, which were derived from oxidation involving the nitrogen atom(1)) and Cope elimination as well as Polonovski-like fragmentation. All of those new compounds (5-12) were fully characterized.

引用

页码：267 / 270

页数：4