An HIV-infected infant with Bacille Calmette-Guerin disease, recurrent and multidrug-resistant tuberculosis complicated by acute cor pulmonale and hepatitis while on antiretroviral therapy

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作者
van Montfrans, J. M. [1 ]
Rabie, H.
Schaaf, H. S.
Hesseling, A. C.
Cotton, M. F.
Shipton, S. E.
Victor, T.
机构
[1] Tygerberg Children Hosp, Dept Paediat Infect Dis, Tygerberg, South Africa
[2] Red Cross War Mem Childrens Hosp, Dept Paediat Cardiol, Cape Town, South Africa
[3] Univ Stellenbosch, Fac Hlth Sci, MRC Unit Cellular Biochem, Tygerberg, South Africa
[4] Wilhelmina Childrens Hosp, Dept Paediat, Utrecht, Netherlands
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R51 [传染病];
学科分类号
100401 ;
摘要
We describe the management of an HIV-infected infant with multisystem disease. The infant presented with severe disease at 3 months of age. Initiation of antiretroviral therapy (ART) was delayed through initial lack of access, after which she developed immune reconstitution inflammatory syndrome to BCG. At this time she was also infected with Mycobacterium tuberculosis, with a later recurrence due to multidrug-resistant (MDR) tuberculosis (TB). During this episode she presented with acute cor pulmonale, possibly due to a pulmonary embolus and also transaminitis. Although such infants are seen frequently in sub-Saharan Africa, there are few guidelines or case descriptions to assist clinicians.
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页码:49 / +
页数:3
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