A new NPY-antagonist strongly stimulates apoptosis and lipolysis on white adipocytes in an obesity model

被引：30

作者：

Margareto, J

Aguado, M

Osés-Prieto, JA

Rivero, I

Monge, A

Aldana, I

Marti, A

Martínez, JA

机构：

[1] Univ Navarra, Dept Physiol & Nutr, Pamplona 31008, Spain

[2] Univ Navarra, Dept Biochem, Pamplona 31008, Spain

[3] Univ Navarra, Dept Organ & Pharmaceut Chem, Pamplona 31008, Spain

来源：

LIFE SCIENCES | 2000年 / 68卷 / 01期

关键词：

NPY-antagonist; obesity; white adipose tissue; high-fat diets; apoptosis; lipolysis;

D O I：

10.1016/S0024-3205(00)00916-4

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Neuropeptide Y (NPY) is a 36 amino acid peptide released in central and peripheral mammalian neurons, which appears to contribute to adiposity regulation by increasing food intake, thus promoting weight gain on animals. Nevertheless, little is known about NPY direct actions on white adipocytes. This trial, which was designed to test the possible effects of a new NPY antagonist, S.A.0204, on white adipose tissue,revealed that the administration of this novel molecule strongly ex vivo stimulates apoptosis and lipolysis in animals fed on a high-fat diet. (C) 2000 Elsevier Science Inc. All rights reserved.

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页码：99 / 107

页数：9

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