Primaquine-based ionic liquids as a novel class of antimalarial hits

被引：25

作者：

Ferraz, Ricardo ^{[1
,2
]}

Noronha, Joana ^{[1
]}

Murtinheira, Fernanda ^{[3
]}

Nogueira, Fatima ^{[3
]}

Machado, Marta ^{[4
]}

Prudencio, Miguel ^{[4
]}

Parapini, Silvia ^{[5
]}

D'Alessandro, Sarah ^{[5
]}

Teixeira, Catia ^{[1
]}

Gomes, Ana ^{[1
]}

Prudencio, Cristina ^{[2
,6
]}

Gomes, Paula ^{[1
]}

机构：

[1] Univ Porto, Dept Quim & Bioquim, UCIBIO REQUIMTE, Fac Ciencias, Rua Campo Alegre 687, P-4169007 Oporto, Portugal

[2] Inst Politecn Porto, Ciencias Quim & Biomol, CISA, Escola Super Tecnol Saude Porto, Rua Valente Perfeito 322, P-4400330 Vila Nova De Gaia, Portugal

[3] Univ Nova Lisboa, IHMT, GHTM, Rua Junqueira 100, P-1349008 Lisbon, Portugal

[4] Univ Lisbon, Inst Med Mol, Fac Med, Ave Prof Egas Moniz, P-1649028 Lisbon, Portugal

[5] Univ Milan, Dipartimento Sci Farmacol & Biomol, Via Pascal 36, I-20133 Milan, Italy

[6] Univ Porto, I3S, Rua Alfredo Allen 208, P-4200135 Oporto, Portugal

来源：

RSC ADVANCES | 2016年 / 6卷 / 61期

基金：

比尔及梅琳达.盖茨基金会;

关键词：

LIVER-STAGE; RESISTANT-BACTERIA; MALARIA; AMPICILLIN; ANALOGS; DRUGS; ACID;

D O I：

10.1039/c6ra10759a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Ionic liquids derived from active pharmaceutical ingredients may open new perspectives towards low-cost rescuing of classical drugs. Thus, we have synthesized novel ionic liquids derived from the antimalarial drug primaquine, and evaluated them in vitro against three stages of malaria parasites. Results from this unprecedented approach open a new chapter in the history of antimalarial drugs.

引用

页码：56134 / 56138

页数：5

共 28 条

[1]

[Anonymous], 2015, MOL OP ENV MOE 2015

[2] In search of pure liquid salt forms of aspirin: ionic liquid approaches with acetylsalicylic acid and salicylic acid [J].