Therapy-related myeloid neoplasms: clinical perspectives

被引：23

作者：

Fianchi, Luana ^{[1
]}

Criscuolo, Marianna ^{[1
]}

Fabiani, Emiliano ^{[2
]}

Falconi, Giulia ^{[2
]}

Maraglino, Alessio Maria Edoardo ^{[1
]}

Voso, Maria Teresa ^{[2
]}

Pagano, Livio ^{[1
]}

机构：

[1] Fdn Policlin Univ A Gemelli, IRCCS, Dept Radiol Sci Radiotherapy & Hematol, Largo A Gemelli 8, I-00168 Rome, Italy

[2] Univ Roma Tor Vergata, Dept Biomed & Prevent, Rome, Italy

来源：

ONCOTARGETS AND THERAPY | 2018年 / 11卷

关键词：

therapy-related myeloid neoplasm; leukemia; prognosis; secondary leukemia; secondary myelodysplastic syndrome; WORLD-HEALTH-ORGANIZATION; MYELODYSPLASTIC SYNDROMES; CLONAL HEMATOPOIESIS; PROGNOSTIC MODEL; LEUKEMIA; RISK; MUTATIONS; SURVIVAL; EFFICACY; CLASSIFICATION;

D O I：

10.2147/OTT.S101333

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Therapy-related myeloid neoplasms (t-MNs) are a complication of cytotoxic treatment for primary tumors and autoimmune diseases. t-MNs result from a complex interaction between individual predisposition and exposition to toxic agents. Some different biological and clinical characteristics can be recognized according to the type of anticancer drug. Compared to de novo myeloid neoplasms, prognosis of t-MN is dismal. Age and karyotype are the most important prognostic factors for t-MN, which should be treated with frontline chemotherapy treatments that are appropriate for patients with myelodysplastic syndrome (MDS) and de novo acute myeloid leukemia (AML) with similar disease characteristics. Allogeneic stem cell transplantation should be considered particularly for unfavorable karyotypes and younger patients with aggressive disease.

引用

页码：5909 / 5915

页数：7

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