Heteromeric TRP Channels in Lung Inflammation

被引：15
作者：
Zergane, Meryam [1 ,2 ,3 ]
Kuebler, Wolfgang M. [1 ,2 ,3 ,4 ,5 ,6 ,7 ]
Michalick, Laura [1 ,2 ,3 ,4 ]
机构：
[1] Charite Univ Med Berlin, Inst Physiol, D-10117 Berlin, Germany
[2] Humboldt Univ, Freie Univ Berlin, D-10117 Berlin, Germany
[3] Berlin Inst Hlth, D-10117 Berlin, Germany
[4] German Ctr Cardiovasc Res DZHK, D-10785 Berlin, Germany
[5] German Ctr Lung Res DZL, D-35392 Giessen, Germany
[6] St Michaels Hosp, Keenan Res Ctr Biomed Sci, Toronto, ON M5B 1W8, Canada
[7] Univ Toronto, Dept Surg & Physiol, Toronto, ON M5S 1A8, Canada
来源：
CELLS | 2021年 / 10卷 / 07期
关键词：
heteromeric TRP assemblies; pulmonary inflammation; endothelial permeability; TRPC3; 6; TRPV1; 4; TRPC1; RECEPTOR POTENTIAL CHANNELS; ATOMIC-FORCE MICROSCOPY; OPERATED CA2+ ENTRY; TRPC3/6; CHANNELS; ANKYRIN REPEAT; VANILLOID; ACTIVATION; EXPRESSION; PROTEINS; INJURY;
D O I：
10.3390/cells10071654
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Activation of Transient Receptor Potential (TRP) channels can disrupt endothelial barrier function, as their mediated Ca2+ influx activates the CaM (calmodulin)/MLCK (myosin light chain kinase)-signaling pathway, and thereby rearranges the cytoskeleton, increases endothelial permeability and thus can facilitate activation of inflammatory cells and formation of pulmonary edema. Interestingly, TRP channel subunits can build heterotetramers, whereas heteromeric TRPC1/4, TRPC3/6 and TRPV1/4 are expressed in the lung endothelium and could be targeted as a protective strategy to reduce endothelial permeability in pulmonary inflammation. An update on TRP heteromers and their role in lung inflammation will be provided with this review.
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页数：20
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