Novel 2′-hydroxylfurylchalcones: synthesis and biological activity

被引:4
作者
Deng, Yunfei [1 ]
He, Yuan [1 ]
Zhan, Taisong [1 ]
Huang, Qingchun [1 ]
机构
[1] E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China
关键词
2 '-Hydroxylfurylchalcone; Herbicides; Antifungal activity; LICOCHALCONE-A; CHALCONES; ANALOGS; AGENTS; DERIVATIVES; DESIGN;
D O I
10.1016/j.carres.2010.05.017
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Twelve novel 2'-hydroxylfurylchalcones have been synthesized by Claisen-Schmidt condensation with galactosylisomaltol, a reagent prepared from lactose. The procedures are environmentally benign and economical. All the compounds are identified by IR, (1)H NMR and (13)C NMR spectroscopy and by mass spectrometry. Preliminary bioassays indicate that all the title compounds show moderately high herbicidal activities against the height and/or the fresh weight of the seedlings of cucumber, rape, amaranth, wheat, sorghum and Chinese sprangletop at 7.5 g of active ingredient per hm(2). However, the compounds exhibit weak fungicidal activities against cucumber powdery mildew, and no activities against rice blast, cucumber grey mould and cucumber downy mildew. The structure-activity relationships are discussed. The present work demonstrates that 2'-hydroxylfurylchalcones could be used as potential lead compounds for further study of novel herbicides. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码:1872 / 1876
页数:5
相关论文
共 23 条
[21]   Antibacterial activity of licochalcone A against spore-forming bacteria [J].
Tsukiyama, RI ;
Katsura, H ;
Tokuriki, N ;
Kobayashi, M .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2002, 46 (05) :1226-1230
[22]   Synthetic chalcones as potential anti-inflammatory and cancer chemopreventive agents [J].
Won, SJ ;
Liu, CT ;
Tsao, LT ;
Weng, JR ;
Ko, HH ;
Wang, JP ;
Lin, CN .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2005, 40 (01) :103-112
[23]   Antitumor agents.: Part 202:: Novel 2′-amino chalcones:: Design, synthesis and biological evaluation [J].
Xia, Y ;
Yang, ZY ;
Xia, P ;
Bastow, KF ;
Nakanishi, Y ;
Lee, KH .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2000, 10 (08) :699-701