Polymorphisms in DNA repair genes and risk of non-Hodgkin lymphoma in a pooled analysis of three studies

被引：18

作者：

Shen, Min

Menashe, Idan ^{[1
]}

Morton, Lindsay M.

Zhang, Yawei ^{[2
]}

Armstrong, Bruce ^{[3
]}

Wang, Sophia S.

Lan, Qing

Hartge, Patricia

Purdue, Mark P.

Cerhan, James R. ^{[4
]}

Grulich, Andrew ^{[5
]}

Cozen, Wendy ^{[6
]}

Yeager, Meredith ^{[7
]}

Holford, Theodore R. ^{[2
]}

Vajdic, Claire M. ^{[8
]}

Davis, Scott ^{[9
,10
]}

Leaderer, Brian ^{[2
]}

Kricker, Anne ^{[3
]}

Severson, Richard K. ^{[11
]}

Zahm, Shelia H.

Chatterjee, Nilanjan

Rothman, Nathaniel

Chanock, Stephen J. ^{[7
]}

Zheng, Tongzhang ^{[2
]}

机构：

[1] NCI, Biostat Branch, Div Canc Epidemiol & Genet, DHHS,NIH, Rockville, MD 20852 USA

[2] Yale Univ, Sch Med, Dept Epidemiol & Publ Hlth, New Haven, CT 06510 USA

[3] Univ Sydney, Sydney Sch Publ Hlth, Sydney, NSW 2006, Australia

[4] Mayo Clin, Div Epidemiol, Coll Med, Rochester, MN USA

[5] Univ New S Wales, Natl Ctr HIV Epidemiol & Clin Res, Sydney, NSW, Australia

[6] Univ So Calif, Kenneth Norris Jr Comprehens Canc Ctr, Los Angeles, CA 90033 USA

[7] NCI, Core Genotyping Facil, Adv Technol Ctr, DHHS,NIH, Gaithersburg, MD USA

[8] Univ New S Wales, Canc Res Ctr, Prince Wales Clin Sch, Sydney, NSW, Australia

[9] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA

[10] Univ Washington, Seattle, WA 98195 USA

[11] Wayne State Univ, Dept Family Med, Detroit, MI USA

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2010年 / 151卷 / 03期

关键词：

non-Hodgkin lymphoma; DNA repair; single nucleotide polymorphism; pooled analysis; LIGASE-IV; PROTEIN; CELLS; BLM;

D O I：

10.1111/j.1365-2141.2010.08364.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

P>Genetic variations in DNA repair genes are thought to play an important role in the pathogenesis and development of non-Hodgkin lymphoma (NHL). To further explore this hypothesis, we genotyped 319 tag single nucleotide polymorphisms (SNPs) in 27 DNA repair gene regions in 1946 cases and 1808 controls pooled from three population-based case-control studies of NHL in the US and Australia. Relative risks of NHL and NHL subtypes in relation to SNP genotypes were assessed using logistic regression. Associations of gene regions and pathways with NHL or NHL subtypes were explored using the minP and tail-strength statistics, respectively. Overall, genetic polymorphisms within the DNA repair pathway were associated with NHL (P = 0 center dot 005). Similar associations were seen with the double-strand break repair (P = 0 center dot 02) and nucleotide excision repair (P = 0 center dot 04) pathways. Five SNPs (BLM rs441399, RAD50 rs2237060, FAM82A2 rs2304583, ERCC3 rs4150506, and XRCC4 rs13178127) were particularly noteworthy because their gene regions were significantly associated with NHL or NHL subtypes (minP < 0 center dot 05), or because of high level of statistical significance (P < 0 center dot 005) and consistent findings across the three studies. These results support the hypothesis that common genetic polymorphisms in human DNA repair genes may modify the risk of NHL.

引用

页码：239 / 244

页数：6

共 14 条

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