From skin to the treatment of diseases - the possibilities of iPS cell research in dermatology

被引：24

作者：

Galach, Marta ^{[1
]}

Utikal, Jochen ^{[1
]}

机构：

[1] Ruprecht Karl Univ Heidelberg, Univ Med Ctr Mannheim, Dept Dermatol Venereol & Allergol, D-68135 Mannheim, Germany

来源：

EXPERIMENTAL DERMATOLOGY | 2011年 / 20卷 / 06期

关键词：

dermatology; iPS cells; iPSCs; reprogramming; stem cell; PLURIPOTENT STEM-CELLS; SOMATIC-CELLS; HUMAN FIBROBLASTS; HIGH-EFFICIENCY; MATURE B; GENERATION; MOUSE; EXPRESSION; INDUCTION; DIFFERENTIATION;

D O I：

10.1111/j.1600-0625.2011.01282.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Induced pluripotent stem cells (iPSCs) can be generated from different somatic cell types through ectopic expression of a set of transcription factors. iPSCs acquire all the features of embryonic stem cells (ESCs) including pluripotency and can thus give rise to any cell type of the body. iPSCs comparable with ESCs are amenable for the correction of gene mutations by homologous recombination. Patient-derived iPSCs may thus be an ideal source for studying diseases in vitro and for treating different disorders in the clinic. In this review, we summarize recent advances and possibilities of iPSC research with focus on the field of dermatology.

引用

页码：523 / 528

页数：6

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