Hypoxia-inducible factor 1α in the central nervous system of the scallop Mizuhopecten yessoensis Jay, 1857 (Bivalvia: Pectinidae) during anoxia and elevated temperatures

An immunocytochemical method was used to study the distribution of hypoxia-inducible factor 1 alpha (HIF-1 alpha) in the central nervous system (CNS) of the scallop Mizuhopecten yessoensis (Jay, 1857) (Bivalvia: Pectinidae) under anoxia and elevated temperatures. HIF-1 alpha was not detected in the CNS of control mollusks. After 2 h anoxia, HIF-1 alpha was detected in neurons of the cerebral and visceral ganglia. It was found that a change in HIF-1 alpha immunoreactivity under anoxia had its own dynamics in each of the ganglia; these dynamics depended on the duration of anoxia and the temperature. The presented data indicate the involvement of the transcription factor HIF-1 alpha in providing the compensatory processes that contribute to activation of the neuroprotective mechanisms in the nervous ganglia that control vital functions in M. yessoensis under short-term hypoxia.