Total homocysteine is associated with white matter hyperintensity volume - The Northern Manhattan Study

被引：157
作者：
Wright, CB
Paik, MC
Brown, TR
Stabler, SP
Allen, RH
Sacco, RL
DeCarli, C
机构：
[1] Columbia Univ Coll Phys & Surg, Dept Neurol, New York, NY 10032 USA
[2] Columbia Univ Coll Phys & Surg, Dept Biostat, New York, NY 10032 USA
[3] Columbia Univ Coll Phys & Surg, Dept Radiol & Biomed Engn, New York, NY 10032 USA
[4] Columbia Univ Coll Phys & Surg, Gertrude H Sergievsky Ctr, New York, NY 10032 USA
[5] Mailman Sch Publ Hlth, New York, NY USA
[6] Univ Colorado, Sch Med, Dept Med, Denver, CO USA
[7] Univ Calif Davis, Ctr Neurosci, Sacramento, CA 95817 USA
[8] Univ Calif Davis, Dept Neurol, Sacramento, CA 95817 USA
来源：
STROKE | 2005年 / 36卷 / 06期
关键词：
homocysteine; magnetic resonance imaging; white matter;
D O I：
10.1161/01.STR.0000165923.02318.22
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Background-Total homocysteine (tHcy) has been implicated as a risk factor for stroke and dementia, but the mechanism is unclear. White matter hyperintensities may be a risk factor for both, but studies of the relationship between tHcy and quantitative measures of white matter hyperintensity volume (WMHV) are lacking, especially in minority populations. Methods-A community-based sample of 259 subjects with baseline tHcy levels underwent pixel-based quantitative measurement of WMHV. We examined the relationship between tHcy and WMHV adjusting for age, sociodemographics, vascular risk factors, and B-12 deficiency. Results-Higher levels of tHcy were associated with WMHV adjusting for sociodemographics and vascular risk factors. Conclusions-These cross-sectional data provide evidence that tHcy is a risk factor for white matter damage.
引用
收藏
页码：1207 / 1211
页数：5
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