Intramolecular cyclization of 1-(2-arylethyl)tetrahydro-6-hydroxy-1H-pyrimidin-2-thiones: effect of substituents on reactivity

被引：6

作者：

Fisuyk, Alexander S. ^{[1
]}

Mukanov, Aleksey Y. ^{[1
]}

Poendaev, Nikolay V. ^{[1
]}

机构：

[1] Omsk FM Dostoevsky State Univ, Omsk 644077, Russia

来源：

MOLECULAR DIVERSITY | 2010年 / 14卷 / 03期

关键词：

4H-Pyrimido[6,1-a]isoquinolin-4-thiones; Pyrido[3,4-b]indole-4-thiones; Cascade cyclization; Structure-reaction conditions correlation;

D O I：

10.1007/s11030-010-9239-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Convenient synthetic procedures for 1,2,3,6,7, 11b-hexahydro-4H-pyrimido[6, 1 -a] isoquinolin-4-thiones and 2,3,6,7,12,12b-hexahydro-1H-pyrimido[1',6':1,2]pyrido[3,4-b]indole-4-thiones have been developed. Structural factors which influence on a cascade cyclization process have been elucidated.

引用

页码：455 / 462

页数：8

共 10 条

[1]

[Anonymous], [No title captured]

[2]

DEBOOTH RFG, 1987, BIOCHEM PHARMACOL, V36, P3517, DOI DOI 10.1016/0006-2952(87)90334-0

[3] Synthesis of 3-isothiocyanatopropion- and -butyraldehyde diethyl acetals and their reactions with N-nucleophiles [J].

Fisyuk, A. S. ;

Mukanov, A. Yu. .

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2006, 42 (09) :1269-1274

[4]

Fisyuk A. S., 2003, CHEM HETEROCYCL COMP, V39, p[307, 277], DOI DOI 10.1023/A:1023701415525

[5]

Ignatova L. A., 1985, CHEM HETEROCYCL COMP, V21, P218, DOI DOI 10.1007/BF00504213

[6] A DIASTEREOSELECTIVE SYNTHESIS OF 7-ARYLPYRIMIDO[6,1-A]ISOQUINOLINES THROUGH N-ACYLIMINIUM ION CYCLIZATION [J].

KANO, S ;

YUASA, Y .

HETEROCYCLES, 1985, 23 (11) :2907-2911

[7]

KANO S, 1984, SYNTHESIS-STUTTGART, P1071

[8] TREQUINSIN, A POTENT NEW ANTIHYPERTENSIVE VASODILATOR IN THE SERIES OF 2-(ARYLIMINO)-3-ALKYL-9,10-DIMETHOXY-3,4,6,7-TETRAHYDRO-2H-PYRIMIDO[6,1-A]ISOQUINOLIN-4-ONES [J].

LAL, B ;

DOHADWALLA, AN ;

DADKAR, NK ;

DSA, A ;

DESOUZA, NJ .

JOURNAL OF MEDICINAL CHEMISTRY, 1984, 27 (11) :1470-1480

[9]

PERETOKIN AV, 1985, ZH ORG KHIM+, V21, P1004

[10]

Uvarova N.A., 1990, CHEM HETEROCYCL COMP, V26, P1383, DOI DOI 10.1007/BF00473968

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