Regulation of sleep homeostasis by sexual arousal

被引:50
作者
Beckwith, Esteban J. [1 ]
Geissmann, Quentin [1 ]
French, Alice S. [1 ]
Gilestro, Giorgio F. [1 ]
机构
[1] Imperial Coll London, Dept Life Sci, London, England
基金
英国生物技术与生命科学研究理事会; 欧盟地平线“2020”; 英国惠康基金;
关键词
DROSOPHILA-MELANOGASTER; COURTSHIP BEHAVIOR; GUSTATORY NEURONS; NEURAL CIRCUITS; OCTOPAMINE; MEMORY; GENES; DRIVE; IDENTIFICATION; ATTRACTION;
D O I
10.7554/eLife.27445
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
In all animals, sleep pressure is under continuous tight regulation. It is universally accepted that this regulation arises from a two-process model, integrating both a circadian and a homeostatic controller. Here we explore the role of environmental social signals as a third, parallel controller of sleep homeostasis and sleep pressure. We show that, in Drosophila melanogaster males, sleep pressure after sleep deprivation can be counteracted by raising their sexual arousal, either by engaging the flies with prolonged courtship activity or merely by exposing them to female pheromones.
引用
收藏
页数:38
相关论文
共 74 条
[1]  
[Anonymous], GGPLOT2 ELEGANT GRAP
[2]   Circadian Period Integrates Network Information Through Activation of the BMP Signaling Pathway [J].
Beckwith, Esteban J. ;
Axel Gorostiza, E. ;
Berni, Jimena ;
Rezaval, Carolina ;
Perez-Santangelo, Agustin ;
Nadra, Alejandro D. ;
Fernanda Ceriani, Maria .
PLOS BIOLOGY, 2013, 11 (12)
[3]   CONTROLLING THE FALSE DISCOVERY RATE - A PRACTICAL AND POWERFUL APPROACH TO MULTIPLE TESTING [J].
BENJAMINI, Y ;
HOCHBERG, Y .
JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-STATISTICAL METHODOLOGY, 1995, 57 (01) :289-300
[4]  
Borbely A A, 1982, Hum Neurobiol, V1, P195
[5]   Sleep homeostasis and models of sleep regulation [J].
Borbély, AA ;
Achermann, P .
JOURNAL OF BIOLOGICAL RHYTHMS, 1999, 14 (06) :557-568
[6]   ANIMAL SLEEP - A REVIEW OF SLEEP DURATION ACROSS PHYLOGENY [J].
CAMPBELL, SS ;
TOBLER, I .
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 1984, 8 (03) :269-300
[7]  
Carpenter J, 2000, STAT MED, V19, P1141, DOI 10.1002/(SICI)1097-0258(20000515)19:9<1141::AID-SIM479>3.0.CO
[8]  
2-F
[9]   Genetic and neuronal mechanisms governing the sex-specific interaction between sleep and sexual behaviors in Drosophila [J].
Chen, Dandan ;
Sitaraman, Divya ;
Chen, Nan ;
Jin, Xin ;
Han, Caihong ;
Chen, Jie ;
Sun, Mengshi ;
Baker, Bruce S. ;
Nitabach, Michael N. ;
Pan, Yufeng .
NATURE COMMUNICATIONS, 2017, 8
[10]   Is sleep essential? [J].
Cirelli, Chiara ;
Tononi, Giulio .
PLOS BIOLOGY, 2008, 6 (08) :1605-1611