(±)-Japonicols A-D, Acylphloroglucinol-Based Meroterpenoid Enantiomers with Anti-KSHV Activities from Hypericum japonicum

被引：47

作者：

Hu, Linzhen ^{[1
,2
]}

Xue, Yongbo ^{[2
]}

Zhang, Jinwen ^{[3
]}

Zhu, Hucheng ^{[2
]}

Chen, Chunmei ^{[2
]}

Li, Xiao-Nain ^{[4
]}

Liu, Junjun ^{[2
]}

Wang, Zhenzhen ^{[2
]}

Zhang, Yu ^{[1
]}

Zhang, Yonghui ^{[2
]}

机构：

[1] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Wuhan 430022, Peoples R China

[2] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Wuhan 430030, Hubei Province, Peoples R China

[3] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Wuhan 430030, Peoples R China

[4] Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2016年 / 79卷 / 05期

基金：

中国国家自然科学基金;

关键词：

SARCOMA-ASSOCIATED HERPESVIRUS; KAPOSIS-SARCOMA; PHLOROGLUCINOL DERIVATIVES; CELL; EXPRESSION; APOPTOSIS; LEUKEMIA; CANCER;

D O I：

10.1021/acs.jnatprod.5b01119

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

(+/-)-Japonicols A D (1a/1b-4a/4b), four pairs of new phloroglucinol-based terpenoid enantiomers, were isolated from Hypericum japonicum. Their absolute configurations were confirmed through comparison of their experimental and calculated electronic circular dichroism spectra and single -crystal X-ray diffraction analyses. Compounds 1a/1b, 2a/2b, and 3a/ 3b possess 2-oxabicyclo[3.3.1]nonane, pyrano[3,2-b]pyran, and benzo[b]cyclopenta[e]oxepine ring systems, respectively. The effects of the phloroglucinols on anti-Kaposi's sarcoma -associated herpesvirus were assessed, and 2a exhibited a moderate inhibitory effect, with an EC50 value of 8.75 mu M and a selectivity index of 16.06.

引用

页码：1322 / 1328

页数：7

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