Elevated microsomal prostaglandin-E synthase-1 in Alzheimer's disease

被引：51

作者：

Chaudhry, Uzma A. ^{[1
]}

Zhuang, Hean ^{[1
]}

Crain, Barbara J. ^{[2
]}

Dore, Sylvain ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Anesthesiol Crit Care Med, Baltimore, MD 21218 USA

[2] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD USA

来源：

ALZHEIMERS & DEMENTIA | 2008年 / 4卷 / 01期

关键词：

beta-amyloid; cyclooxygenase; middle frontal gyrus; neuroinflammation; PGES;

D O I：

10.1016/j.jalz.2007.10.015

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: The proinflammatory prostaglandin E, (PGE(2)) fluctuates over time in the cerebrospinal fluid of patients with Alzheimer's disease (AD), but the cerebral distribution and expression patterns of microsomal prostaglandin-E synthase (mPGES)-1 have not been compared with those of normal human brains. Methods: Middle frontal gyrus tissue from AD and age-matched control brains was analyzed by Western blot, immunofluorescence, and immunohistochemistry with mPGES-1-specific antibodies. Results: Western blotting revealed that mPGES-1 expression was significantly elevated in AD tissue. Furthermore, immunofluorescence of mPGES-1 was observed in neurons, microglia, and endothelial cells of control and AD tissue. Although mPGES-1 was consistently present in astrocytes of control tissue, it was present in only some astrocytes of AD tissue. Immunohistochemical staining suggested that mPGES-1 was elevated in pyramidal neurons of AD tissue when compared with controls. Conclusions: The results suggest that mPGES-1 is normally expressed constitutively in human neurons, microglia, astrocytes, and endothelial cells but is up-regulated in AD. (C) 2008 The Alzheimer's Association. All rights reserved.

引用

页码：6 / 13

页数：8

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