Differential effects of BTK inhibitors ibrutinib and zanubrutinib on NK-cell effector function in patients with mantle cell lymphoma

被引:49
作者
Flinsenberg, Thijs W. H. [1 ,2 ]
Tromedjo, Charnelle C. [1 ,2 ]
Hu, Nan [3 ]
Liu, Ye [3 ]
Guo, Yin [3 ]
Thia, Kevin Y. T. [1 ,2 ]
Noori, Tahereh [1 ,2 ]
Song, Xiaomin [3 ]
Aw Yeang, Han X. [1 ,2 ,4 ]
Tantalo, Daniela G. [1 ,2 ]
Handunnetti, Sasanka [5 ,6 ,7 ]
Seymour, John F. [5 ,6 ,7 ]
Roberts, Andrew W. [5 ,6 ,7 ]
Ritchie, David [5 ,6 ,7 ,8 ,9 ]
Koldej, Rachel [5 ,8 ,9 ]
Neeson, Paul J. [1 ,2 ,4 ]
Wang, Lai [3 ]
Trapani, Joseph A. [1 ,2 ,4 ]
Tam, Constantine S. [5 ,6 ,7 ]
Voskoboinik, Ilia [1 ,2 ,4 ]
机构
[1] Peter MacCallum Canc Ctr, Canc Immunol Program, Melbourne, Vic, Australia
[2] Peter MacCallum Canc Ctr, Rosie Lew Immunotherapy Program, Melbourne, Vic, Australia
[3] BeiGene LTD, Beijing, Peoples R China
[4] Univ Melbourne, Sir Peter MacCallum Dept Oncol, Parkville, Vic, Australia
[5] Univ Melbourne, Fac Med Dent & Hlth Sci, Parkville, Vic, Australia
[6] Peter MacCallum Canc Ctr, Dept Clin Haematol, Melbourne, Vic, Australia
[7] Royal Melbourne Hosp, Melbourne, Vic, Australia
[8] ACRF Translat Res Lab, Parkville, Vic, Australia
[9] Royal Melbourne Hosp, Parkville, Vic, Australia
基金
英国医学研究理事会;
关键词
D O I
10.3324/haematol.2019.220590
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:E76 / E79
页数:4
相关论文
共 15 条
  • [1] [Anonymous], 2015, BLOOD
  • [2] Ibrutinib interferes with the cell-mediated anti-tumor activities of therapeutic CD20 antibodies: implications for combination therapy
    Da Roit, Fabio
    Engelberts, Patrick J.
    Taylor, Ronald P.
    Breij, Esther C. W.
    Gritti, Giuseppe
    Rambaldi, Alessandro
    Introna, Martino
    Parren, Paul W. H. I.
    Beurskens, Frank J.
    Golay, Josee
    [J]. HAEMATOLOGICA, 2015, 100 (01) : 77 - 86
  • [3] Ibrutinib is an irreversible molecular inhibitor of ITK driving a Th1-selective pressure in T lymphocytes
    Dubovsky, Jason A.
    Beckwith, Kyle A.
    Natarajan, Gayathri
    Woyach, Jennifer A.
    Jaglowski, Samantha
    Zhong, Yiming
    Hessler, Joshua D.
    Liu, Ta-Ming
    Chang, Betty Y.
    Larkin, Karilyn M.
    Stefanovski, Matthew R.
    Chappell, Danielle L.
    Frissora, Frank W.
    Smith, Lisa L.
    Smucker, Kelly A.
    Flynn, Joseph M.
    Jones, Jeffrey A.
    Andritsos, Leslie A.
    Maddocks, Kami
    Lehman, Amy M.
    Furman, Richard
    Sharman, Jeff
    Mishra, Anjali
    Caligiuri, Michael A.
    Satoskar, Abhay R.
    Buggy, Joseph J.
    Muthusamy, Natarajan
    Johnson, Amy J.
    Byrd, John C.
    [J]. BLOOD, 2013, 122 (15) : 2539 - 2549
  • [4] The Broad Spectrum of Human Natural Killer Cell Diversity
    Freud, Aharon G.
    Mundy-Bosse, Bethany L.
    Yu, Jianhua
    Caligiuri, Michael A.
    [J]. IMMUNITY, 2017, 47 (05) : 820 - 833
  • [5] CD62L expression identifies a unique subset of polyfunctional CD56dim NK cells
    Juelke, Kerstin
    Killig, Monica
    Luetke-Eversloh, Merlin
    Parente, Eliana
    Gruen, Joachim
    Morandi, Barbara
    Ferlazzo, Guido
    Thiel, Andreas
    Schmitt-Knosalla, Isabela
    Romagnani, Chiara
    [J]. BLOOD, 2010, 116 (08) : 1299 - 1307
  • [6] Differential regulation of human NK cell-mediated cytotoxicity by the tyrosine kinase Itk
    Khurana, Dianne
    Arneson, Laura N.
    Schoon, Renee A.
    Dick, Christopher J.
    Leibson, Paul J.
    [J]. JOURNAL OF IMMUNOLOGY, 2007, 178 (06) : 3575 - 3582
  • [7] Ibrutinib antagonizes rituximab-dependent NK cell-mediated cytotoxicity
    Kohrt, Holbrook E.
    Sagiv-Barfi, Idit
    Rafiq, Sarwish
    Herman, Sarah E. M.
    Butchar, Jonathon P.
    Cheney, Carolyn
    Zhang, Xiaoli
    Buggy, Joseph J.
    Muthusamy, Natarajan
    Levy, Ronald
    Johnson, Amy J.
    Byrd, John C.
    [J]. BLOOD, 2014, 123 (12) : 1957 - 1960
  • [8] Kuo H, 2016, BLOOD, V126, P4140
  • [9] Functional significance of CD57 expression on human NK cells and relevance to disease
    Nielsen, Carolyn M.
    White, Matthew J.
    Goodier, Martin R.
    Riley, Eleanor M.
    [J]. FRONTIERS IN IMMUNOLOGY, 2013, 4
  • [10] Three BTK-Specific Inhibitors, in Contrast to Ibrutinib, Do Not Antagonize Rituximab-Dependent NK-Cell Mediated Cytotoxicity
    Rajasekaran, Narendiran
    Sadaram, Mohith
    Hebb, Jonathan
    Sagiv-Barfi, Idit
    Ambulkar, Sid
    Rajapaksa, Amanda
    Chang, Serena
    Chester, Cariad
    Waller, Erin
    Wang, Lai
    Lannutti, Brian
    Johnson, Dave
    Levy, Ron
    Kohrt, Holbrook E.
    [J]. BLOOD, 2014, 124 (21)