Roles of Neutrophils in Glioma and Brain Metastases

被引：80

作者：

Lin, Ya-Jui ^{[1
,2
,3
]}

Wei, Kuo-Chen ^{[1
,4
,5
]}

Chen, Pin-Yuan ^{[5
,6
]}

Lim, Michael ^{[3
]}

Hwang, Tsong-Long ^{[2
,7
,8
,9
,10
]}

机构：

[1] Chang Gung Mem Hosp, Dept Neurosurg, Linkou, Taiwan

[2] Chang Gung Univ, Coll Med, Grad Inst Nat Prod, Taoyuan, Taiwan

[3] Stanford Univ, Sch Med, Dept Neurosurg, Stanford, CA 94305 USA

[4] New Taipei Municipal TuCheng Hosp, Chang Gung Med Fdn, Dept Neurosurg, New Taipei, Taiwan

[5] Chang Gung Univ, Sch Med, Taoyuan, Taiwan

[6] Chang Gung Mem Hosp, Dept Neurosurg, Keelung, Taiwan

[7] Chang Gung Univ Sci & Technol, Res Ctr Food & Cosmet Safety, Res Ctr Chinese Herbal Med, Taoyuan, Taiwan

[8] Chang Gung Univ Sci & Technol, Grad Inst Hlth Ind Technol, Taoyuan, Taiwan

[9] Chang Gung Mem Hosp, Dept Anesthesiol, Taoyuan, Taiwan

[10] Ming Chi Univ Technol, Dept Chem Engn, New Taipei, Taiwan

来源：

FRONTIERS IN IMMUNOLOGY | 2021年 / 12卷

关键词：

neutrophils; gliobastoma; brain metastases; neutrophil extracellular traps; nanocarrier; COLONY-STIMULATING FACTOR; TUMOR-ASSOCIATED NEUTROPHILS; TO-LYMPHOCYTE RATIO; MESENCHYMAL STEM-CELLS; EXTRACELLULAR TRAPS PROMOTE; ACTIVATED HUMAN-NEUTROPHILS; BONE-MARROW; G-CSF; MALIGNANT GLIOMA; BLOOD-BRAIN;

D O I：

10.3389/fimmu.2021.701383

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Neutrophils, which are the most abundant circulating leukocytes in humans, are the first line of defense against bacterial and fungal infections. Recent studies have reported the role and importance of neutrophils in cancers. Glioma and brain metastases are the most common malignant tumors of the brain. The tumor microenvironment (TME) in the brain is complex and unique owing to the brain-blood barrier or brain-tumor barrier, which may prevent drug penetration and decrease the efficacy of immunotherapy. However, there are limited studies on the correlation between brain cancer and neutrophils. This review discusses the origin and functions of neutrophils. Additionally, the current knowledge on the correlation between neutrophil-to-lymphocyte ratio and prognosis of glioma and brain metastases has been summarized. Furthermore, the implications of tumor-associated neutrophil (TAN) phenotypes and the functions of TANs have been discussed. Finally, the potential effects of various treatments on TANs and the ability of neutrophils to function as a nanocarrier of drugs to the brain TME have been summarized. However, further studies are needed to elucidate the complex interactions between neutrophils, other immune cells, and brain tumor cells.

引用

页数：19

共 298 条

[1] A CXCL1 Paracrine Network Links Cancer Chemoresistance and Metastasis [J].

Acharyya, Swarnali ;

Oskarsson, Thordur ;

Vanharanta, Sakari ;

Malladi, Srinivas ;

Kim, Juliet ;

Morris, Patrick G. ;

Manova-Todorova, Katia ;

Leversha, Margaret ;

Hogg, Nancy ;

Seshan, Venkatraman E. ;

Norton, Larry ;

Brogi, Edi ;

Massague, Joan .

CELL, 2012, 150 (01) :165-178

[2] Identification of Flt3+ lympho-myeloid stem cells lacking erythro-megakaryocytic potential:: A revised road map for adult blood lineage commitment [J].

Adolfsson, J ;

Månsson, R ;

Buza-Vidas, N ;

Hultquist, A ;

Liuba, K ;

Jensen, CT ;

Bryder, D ;

Yang, LP ;

Borge, OJ ;

Thoren, LAM ;

Anderson, K ;

Sitnicka, E ;

Sasaki, Y ;

Sigvardsson, M ;

Jacobsen, SEW .

CELL, 2005, 121 (02) :295-306

[3] Targeting Inflammatory Pathways for Prevention and Therapy of Cancer: Short-Term Friend, Long-Term Foe [J].

Aggarwal, Bharat B. ;

Vijayalekshmi, R. V. ;

Sung, Bokyung .

CLINICAL CANCER RESEARCH, 2009, 15 (02) :425-430

[4] Intratumoral IL-12 delivery empowers CAR-T cell immunotherapy in a pre-clinical model of glioblastoma [J].

Agliardi, Giulia ;

Liuzzi, Anna Rita ;

Hotblack, Alastair ;

De Feo, Donatella ;

Nunez, Nicolas ;

Stowe, Cassandra L. ;

Friebel, Ekaterina ;

Nannini, Francesco ;

Rindlisbacher, Lukas ;

Roberts, Thomas A. ;

Ramasawmy, Rajiv ;

Williams, Iwan P. ;

Siow, Bernard M. ;

Lythgoe, Mark F. ;

Kalber, Tammy L. ;

Quezada, Sergio A. ;

Pule, Martin A. ;

Tugues, Sonia ;

Straathof, Karin ;

Becher, Burkhard .

NATURE COMMUNICATIONS, 2021, 12 (01)

[5] Albumin and Neutrophil-Lymphocyte Ratio (NLR) Predict Survival in Patients With Pancreatic Adenocarcinoma Treated With SBRT [J].

Alagappan, Muthuraman ;

Pollom, Erqi L. ;

von Eyben, Rie ;

Kozak, Margaret M. ;

Aggarwal, Sonya ;

Poultsides, George A. ;

Koong, Albert C. ;

Chang, Daniel T. .

AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS, 2018, 41 (03) :242-247

[6] Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice [J].

Albrengues, Jean ;

Shields, Mario A. ;

Ng, David ;

Park, Chun Gwon ;

Ambrico, Alexandra ;

Poindexter, Morgan E. ;

Upadhyay, Priya ;

Uyeminami, Dale L. ;

Pommier, Arnaud ;

Kuttner, Victoria ;

Bruzas, Emilis ;

Maiorino, Laura ;

Bautista, Carmelita ;

Carmona, Ellese M. ;

Gimotty, Phyllis A. ;

Fearon, Douglas T. ;

Chang, Kenneth ;

Lyons, Scott K. ;

Pinkerton, Kent E. ;

Trotman, Lloyd C. ;

Goldberg, Michael S. ;

Yeh, Johannes T. -H. ;

Egeblad, Mikala .

SCIENCE, 2018, 361 (6409) :1353-+

[7] Cytokine Patterns in Brain Tumour Progression [J].

Albulescu, Radu ;

Codrici, Elena ;

Popescu, Ionela Daniela ;

Mihai, Simona ;

Necula, Laura Georgiana ;

Petrescu, Daniel ;

Teodoru, Mihaela ;

Tanase, Cristiana Pistol .

MEDIATORS OF INFLAMMATION, 2013, 2013

[8] Production and detection of cold antihydrogen atoms [J].

Amoretti, M ;

Amsler, C ;

Bonomi, G ;

Bouchta, A ;

Bowe, P ;

Carraro, C ;

Cesar, CL ;

Charlton, M ;

Collier, MJT ;

Doser, M ;

Filippini, V ;

Fine, KS ;

Fontana, A ;

Fujiwara, MC ;

Funakoshi, R ;

Genova, P ;

Hangst, JS ;

Hayano, RS ;

Holzscheiter, MH ;

Jorgensen, LV ;

Lagomarsino, V ;

Landua, R ;

Lindelöf, D ;

Rizzini, EL ;

Macri, M ;

Madsen, N ;

Manuzio, G ;

Marchesotti, M ;

Montagna, P ;

Pruys, H ;

Regenfus, C ;

Riedler, P ;

Rochet, J ;

Rotondi, A ;

Rouleau, G ;

Testera, G ;

Variola, A ;

Watson, TL ;

van der Werf, DP .

NATURE, 2002, 419 (6906) :456-459

[9] Type I IFNs induce anti-tumor polarization of tumor associated neutrophils in mice and human [J].

Andzinski, Lisa ;

Kasnitz, Nadine ;

Stahnke, Stephanie ;

Wu, Ching-Fang ;

Gereke, Marcus ;

von Koeckritz-Blickwede, Maren ;

Schilling, Bastian ;

Brandau, Sven ;

Weiss, Siegfried ;

Jablonska, Jadwiga .

INTERNATIONAL JOURNAL OF CANCER, 2016, 138 (08) :1982-1993

[10]

[Anonymous], 1961, Acta Medica Scandinavica, V170, P128, DOI [DOI 10.1111/J.0954-6820.1961.TB00220.X, 10.1111/j.0954-6820.1961.tb00220.x]

← 1 2 3 4 5 6 7 8 9 10 →