Iron(II)-Promoted Synthesis of 2-Aminothiazoles via C-N Bond Formation from Vinyl Azides and Potassium Thiocyanate

被引：26

作者：

Zhang, Guolin ^{[1
]}

Chen, Binhui ^{[1
]}

Guo, Xiao ^{[1
]}

Guo, Shanshan ^{[1
]}

Yu, Yongping ^{[1
]}

机构：

[1] Zhejiang Univ, Coll Pharmaceut Sci, Zhejiang Prov Key Lab Anticanc Drug Res, Hangzhou 310058, Zhejiang, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2015年 / 357卷 / 05期

基金：

美国国家科学基金会;

关键词：

2-aminothiazoles; azides; green chemistry; homogeneous catalysis; iron; ONE-POT SYNTHESIS; EFFICIENT SYNTHESIS; BIOLOGICAL EVALUATION; CATALYZED SYNTHESIS; IRON; PYRROLES; FACILE; DERIVATIVES; INHIBITORS; THIAZOLES;

D O I：

10.1002/adsc.201400856

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A simple protocol to prepare the privileged 2-aminothiazoles promoted by ferrous sulfate heptahydrate via C-N bond formation from vinyl azides and commercially available potassium thiocyanate has been developed. A wide range of vinyl azides are tolerated to afford the expected polysubstituted 2-aminothiazoles in reasonably good yields. The use of the non-toxic substrates and catalyst renders the reaction more environmentally friendly than traditional approaches.

引用

页码：1065 / 1069

页数：5

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