Iron(II)-Promoted Synthesis of 2-Aminothiazoles via C-N Bond Formation from Vinyl Azides and Potassium Thiocyanate

被引：26
|
作者：
Zhang, Guolin [1 ]
Chen, Binhui [1 ]
Guo, Xiao [1 ]
Guo, Shanshan [1 ]
Yu, Yongping [1 ]
机构：
[1] Zhejiang Univ, Coll Pharmaceut Sci, Zhejiang Prov Key Lab Anticanc Drug Res, Hangzhou 310058, Zhejiang, Peoples R China
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2015年 / 357卷 / 05期
基金：
美国国家科学基金会;
关键词：
2-aminothiazoles; azides; green chemistry; homogeneous catalysis; iron; ONE-POT SYNTHESIS; EFFICIENT SYNTHESIS; BIOLOGICAL EVALUATION; CATALYZED SYNTHESIS; IRON; PYRROLES; FACILE; DERIVATIVES; INHIBITORS; THIAZOLES;
D O I：
10.1002/adsc.201400856
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A simple protocol to prepare the privileged 2-aminothiazoles promoted by ferrous sulfate heptahydrate via C-N bond formation from vinyl azides and commercially available potassium thiocyanate has been developed. A wide range of vinyl azides are tolerated to afford the expected polysubstituted 2-aminothiazoles in reasonably good yields. The use of the non-toxic substrates and catalyst renders the reaction more environmentally friendly than traditional approaches.
引用
收藏
页码：1065 / 1069
页数：5
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