Functionalized Nanostructures: Redox-Active Porphyrin Anchors for Supramolecular DNA Assemblies

被引：36

作者：

Borjesson, Karl ^{[1
]}

Wiberg, Joanna ^{[1
]}

El-Sagheer, Afaf H. ^{[2
,3
]}

Ljungdahl, Thomas ^{[4
]}

Martensson, Jerker ^{[1
]}

Brown, Tom ^{[2
]}

Norden, Bengt ^{[1
]}

Albinsson, Bo ^{[1
]}

机构：

[1] Chalmers, Dept Chem & Biol Engn Phys Chem, S-41296 Gothenburg, Sweden

[2] Univ Southampton, Sch Chem, Southampton SO17 1BJ, Hants, England

[3] Suez Canal Univ, Fac Petr & Min Engn, Chem Branch, Dept Sci & Math, Suez, Egypt

[4] Univ Gothenburg, Dept Chem Med Chem, S-41296 Gothenburg, Sweden

来源：

ACS NANO | 2010年 / 4卷 / 09期

基金：

瑞典研究理事会;

关键词：

DNA; nanotechnology; porphyrin; membrane; supramolecular; electron transfer; PHOTOINDUCED ELECTRON-TRANSFER; BRIDGE-ACCEPTOR SYSTEMS; FLOW DICHROISM; MEMBRANE; SCAFFOLD; CONSTRUCTION; FLUORESCENCE; ORIENTATION; DEPENDENCE; LIPOSOMES;

D O I：

10.1021/nn100667b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We have synthesized and studied a supramolecular system comprising a 39-mer DNA with porphyrin-modified thymidine nucleosides anchored to the surface of large unilamellar vesicles (liposomes). Liposome porphyrin binding characteristics, such as orientation, strength, homogeneity, and binding site size, was determined, suggesting that the porphyrin is well suited as a photophysical and redox-active lipid anchor, in comparison to the inert cholesterol anchor commonly used today. Furthermore, the binding characteristics and hybridization capabilities were studied as a function of anchor size and number of anchoring points, properties that are of importance for our future plans to use the addressability of these redox-active nodes in larger DNA-based nanoconstructs. Electron transfer from photoexcited porphyrin to a lipophilic benzoquinone residing in the lipid membrane was characterized by steady-state and time-resolved fluorescence and verified by femtosecond transient absorption.

引用

页码：5037 / 5046

页数：10

共 32 条

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[32] A zinc(II) tetraphenylporphyrin peripherally functionalized with redox-active "trans-[(η5-C5H5)Fe(η5-C5H4)C≡≡C](κ2-dppe)2Ru(C≡≡C)-"substituents: Linear electrochromism and third-order nonlinear optics
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