An aluminum-based MOF and its amine form as novel biological active materials for antioxidant, DNA cleavage, antimicrobial, and biofilm inhibition activities

This article deals with the microwave method synthesis of an aluminum-containing metal-organic framework (MOF), MIL-53(Al) and its amine form, NH2-MIL-53(Al), and the evaluation of the biological activities. It was determined that the synthesized materials have crystalline and microporous structures. While the surface charge of amine-functionalized MIL-53 increased, particle size and surface area decreased compared to pure MIL-53(Al). Synthesized Al-MOFs were tested for antioxidant, antimicrobial, DNA cleavage, and anti-biofilm characteristics. The findings revealed that NH2-MIL-53(Al) scavenged DPPH radical with an inhibition rate of 48.6% at 500 mg/L concentration. The highest ferrous ion chelating activities were found as 70.6% for MIL-53(Al) at 500 mg/L concentration. The antimicrobial properties of MOFs were investigated by using the microdilution technique, and NH2-MIL-53(Al) was more powerful than MIL-53(Al) against test microorganisms. NH2-MIL-53(Al) demonstrated excellent antimicrobial activities against E. hirae at a minimum inhibition concentration (MIC) value of 8 mg/L. In addition, aluminum-based MOFs showed excellent anti-biofilm and nuclease activity. (C) 2022 Elsevier Ltd. All rights reserved.