Role of the multifunctional transcription factor TFII-I in DNA damage repair

被引：8

作者：

Roy, Ananda L. ^{[1
]}

机构：

[1] Natl Inst Hlth, Natl Inst Aging, Biomed Res Ctr, Lab Mol Biol & Immunol, Baltimore, MD 21224 USA

来源：

DNA REPAIR | 2021年 / 106卷

基金：

美国国家卫生研究院;

关键词：

Gene expression; Transcription factor; TFII-I; DNA damage; DNA repair; CELL-CYCLE; BINDING-PROTEIN; PROMOTER ACTIVITY; GENE; GENOME; ACTIVATOR; BAP-135; TARGET; GTF2I;

D O I：

10.1016/j.dnarep.2021.103175

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The multifunctional transcription factor TFII-I, encoded by the GTF2I gene, is implicated in various biological pathways, and associated with multiple human disorders. Evidence is also mounting to suggest that TFII-I is involved in DNA damage repair pathways. Here I bring together these recent observations and suggest a connection between transcriptional and DNA repair functions of TFII-I.

引用

页数：4

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