Targeting Elevated GnRH Pulsatility to Treat Polycystic Ovary Syndrome Comment

被引：14
作者：
Abbara, Ali [1 ]
Dhillo, Waljit S. [1 ]
机构：
[1] Imperial Coll London, Hammersmith Hosp, Sect Endocrinol & Invest Med, London W12 0NN, England
来源：
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | 2021年 / 106卷 / 10期
基金：
英国惠康基金; 英国医学研究理事会; 英国生物技术与生命科学研究理事会;
关键词：
polycystic ovary syndrome; gonadotropin-releasing hormone; neurokinin; 3; receptor; neurokinin B; kisspeptin; dynorphin A neurons (KNDy neurons);
D O I：
10.1210/clinem/dgab422
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页码：E4275 / E4277
页数：3
相关论文
共 8 条
  • [1] Altered expression of the kisspeptin/KISS1R and neurokinin B/NK3R systems in mural granulosa and cumulus cells of patients with polycystic ovarian syndrome
    Blasco, Victor
    Pinto, Francisco M.
    Fernandez-Atucha, Ainhoa
    Prados, Nicolas
    Tena-Sempere, Manuel
    Fernandez-Sanchez, Manuel
    Candenas, Luz
    [J]. JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, 2019, 36 (01) : 113 - 120
  • [2] Neuroendocrine androgen action is a key extraovarian mediator in the development of polycystic ovary syndrome
    Caldwell, Aimee S. L.
    Edwards, Melissa C.
    Desai, Reena
    Jimenez, Mark
    Gilchrist, Robert B.
    Handelsman, David J.
    Walters, Kirsty A.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 114 (16) : E3334 - E3343
  • [3] Randomized Controlled Trial of Neurokinin 3 Receptor Antagonist Fezolinetant for Treatment of Polycystic Ovary Syndrome
    Fraser, Graeme L.
    Obermayer-Pietsch, Barbara
    Laven, Joop
    Griesinger, Georg
    Pintiaux, Axelle
    Timmerman, Dirk
    Fauser, Bart C. J. M.
    Lademacher, Christopher
    Combalbert, Jean
    Hoveyda, Hamid R.
    Ramael, Steven
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2021, 106 (09) : E3519 - E3532
  • [4] The NK3 Receptor Antagonist ESN364 Suppresses Sex Hormones in Men and Women
    Fraser, Graeme L.
    Ramael, Steven
    Hoveyda, Hamid R.
    Gheyle, Lien
    Combalbert, Jean
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2016, 101 (02) : 417 - 426
  • [5] Neurokinin B Receptor Antagonism in Women With Polycystic Ovary Syndrome: A Randomized, Placebo-Controlled Trial
    George, Jyothis T.
    Kakkar, Rahul
    Marshall, Jayne
    Scott, Martin L.
    Finkelman, Richard D.
    Ho, Tony W.
    Veldhuis, Johannes
    Skorupskaite, Karolina
    Anderson, Richard A.
    McIntosh, Stuart
    Webber, Lorraine
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2016, 101 (11) : 4313 - 4321
  • [6] Polycystic οvary syndrome revisited: An interactions network approach
    Geronikolou, Styliani A.
    Pavlopoulou, Athanasia
    Cokkinos, Dennis V.
    Bacopoulou, Flora
    Chrousos, George P.
    [J]. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2021, 51 (09)
  • [7] Clinical and biochemical discriminants between functional hypothalamic amenorrhoea (FHA) and polycystic ovary syndrome (PCOS)
    Phylactou, Maria
    Clarke, Sophie A.
    Patel, Bijal
    Baggaley, Caitlin
    Jayasena, Channa N.
    Kelsey, Tom W.
    Comninos, Alexander N.
    Dhillo, Waljit S.
    Abbara, Ali
    [J]. CLINICAL ENDOCRINOLOGY, 2021, 95 (02) : 239 - 252
  • [8] Neurokinin 3 Receptor Antagonism Ameliorates Key Metabolic Features in a Hyperandrogenic PCOS Mouse Model
    Sucquart, Irene E.
    Nagarkar, Ruchi
    Edwards, Melissa C.
    Paris, Valentina Rodriguez
    Aflatounian, Ali
    Bertoldo, Michael J.
    Campbell, Rebecca E.
    Gilchrist, Robert B.
    Begg, Denovan P.
    Handelsman, David J.
    Padmanabhan, Vasantha
    Anderson, Richard A.
    Walters, Kirsty A.
    [J]. ENDOCRINOLOGY, 2021, 162 (05)
1