L-Proline-catalyzed five-component domino reaction leading to multifunctionalized 1,2,3,4-tetrahydropyridines

被引：44
作者：
Jiang, Huan-Feng [1 ]
Li, Jing-Hao [1 ]
Chen, Zheng-Wang [1 ]
机构：
[1] S China Univ Technol, Sch Chem & Chem Engn, Guangzhou 510640, Peoples R China
来源：
TETRAHEDRON | 2010年 / 66卷 / 51期
基金：
中国国家自然科学基金;
关键词：
ACTIVE METHYLENE-COMPOUNDS; ONE-POT SYNTHESIS; MULTICOMPONENT REACTIONS; 3-COMPONENT REACTION; MANNICH REACTION; ACID; EFFICIENT; AMINES; TETRAHYDROPYRIDINES; DERIVATIVES;
D O I：
10.1016/j.tet.2010.10.041
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Multifunctionalized 1,2,3,4-tetrahydropyridines are concisely synthesized in good yields via L-proline-catalyzed or L-proline/FeCl3-cocatalyzed one-pot multicomponent reactions (MCRs). The MCRs involve a domino hydroamination/prins reaction/Mannich-type reaction/intramolecular dehydration-cyclization process. The molecular structure of 5baa, one of multifunctionalized 1,2,3,4-tetrahydropyridines, was confirmed by single-crystal X-ray diffraction. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：9721 / 9728
页数：8
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