3D Monte Carlo model with direct photon flux recording for optimal optogenetic light delivery

被引：0
|
作者：
Shin, Younghoon [1 ,2 ]
Kim, Dongmok [1 ,2 ]
Lee, Jihoon [1 ,2 ]
Kwon, Hyuk-Sang [1 ,2 ,3 ]
机构：
[1] Dept Biomed Sci & Engn, 123 Cheomdan Gwagiro, Gwangju 61005, South Korea
[2] Gwangju Inst Sci & Technol, 123 Cheomdan Gwagiro, Gwangju 61005, South Korea
[3] Gwangju Inst Sci & Technol, Dept Mech Engn, 123 Cheomdan Gwagiro, Gwangju 61005, South Korea
来源：
OPTOGENETICS AND OPTICAL MANIPULATION | 2017年 / 10052卷
基金：
新加坡国家研究基金会;
关键词：
optogenetics; modeling of stimulating light in optogenetics; Monte Carlo simulation; light propagation in tissue; DESIGN; BRAIN; MEDIA;
D O I：
10.1117/12.2250679
中图分类号：
O43 [光学];
学科分类号：
070207 ; 0803 ;
摘要：
Configuring the light power emitted from the optical fiber is an essential first step in planning in-vivo optogenetic experiments. However, diffusion theory, which was adopted for optogenetic research, precluded accurate estimates of light intensity in the semi-diffusive region where the primary locus of the stimulation is located. We present a 3D Monte Carlo model that provides an accurate and direct solution for light distribution in this region. Our method directly records the photon trajectory in the separate volumetric grid planes for the near-source recording efficiency gain, and it incorporates a 3D brain mesh to support both homogeneous and heterogeneous brain tissue. We investigated the light emitted from optical fibers in brain tissue in 3D, and we applied the results to design optimal light delivery parameters for precise optogenetic manipulation by considering the fiber output power, wavelength, fiber-to-target distance, and the area of neural tissue activation.
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页数：5
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