A facile synthesis of quinazolino[1,4] benzodiazepine alkaloids via reductive N-heterocyclization of N-(2-nitrobenzoyl)amides: Total synthesis of asperlicin C, circumdatin H, and analogues

被引：12
作者：
Al-Said, Naim H. [1 ]
Shawakfeh, Khaled Q. [1 ]
Ibrahim, Mohammad I. [1 ]
Tayyem, Sami H. [1 ]
机构：
[1] Jordan Univ Sci & Technol, Dept Appl Chem Sci, POB 3030, Irbid 22110, Jordan
来源：
ARKIVOC | 2010年
关键词：
1,4-benzodiazepine; N-heterocyclization; asperlicin C; circumdatin H; 1ST TOTAL-SYNTHESIS; CHOLECYSTOKININ ANTAGONISTS; ASPERGILLUS-ALLIACEUS; LUOTONIN-A; SCLEROTIGENIN; CYCLIZATION; AMINES; (-)-BENZOMALVIN; FERMENTATION; DERIVATIVES;
D O I：
10.3998/ark.5550190.0011.926
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A facile and short synthesis of a series of quinazolino[1,4]benzodiazepine alkaloids, including asperlicin C, circumdatin H and some analogues, is reported utilizing coupling of readily available [1,4] benzodiazepine with 2-nitrobenzoyl chlorides, followed by a reductive N-heterocyclization.
引用
收藏
页码：282 / 292
页数：11
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