Research Progress on Fumonisin B1 Contamination and Toxicity: A Review

被引：113

作者：

Chen, Jia ^{[1
]}

Wen, Jun ^{[1
]}

Tang, Yating ^{[1
]}

Shi, Jichao ^{[2
]}

Mu, Guodong ^{[3
]}

Yan, Rong ^{[1
]}

Cai, Jing ^{[1
]}

Long, Miao ^{[1
]}

机构：

[1] Shenyang Agr Univ, Coll Anim Sci & Vet Med, Shenyang 110866, Peoples R China

[2] Liaoning Serv Dev Ctr, Shenyang 110032, Peoples R China

[3] Jilin Ctr Anim Dis Control & Prevent, 4510 Xian Rd, Changchun 130062, Peoples R China

来源：

MOLECULES | 2021年 / 26卷 / 17期

基金：

中国国家自然科学基金;

关键词：

fumonisin B1; toxicity; mechanism; contamination; review; NEURAL-TUBE DEFECTS; ESOPHAGEAL EPITHELIAL-CELLS; SPHINGOLIPID METABOLISM; RAT-KIDNEY; IN-VIVO; DEVELOPMENTAL TOXICITY; HUMAN KERATINOCYTES; DIETARY EXPOSURE; AFLATOXIN B-1; FUSARIUM SPP;

D O I：

10.3390/molecules26175238

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Fumonisin B1 (FB1), belonging to the member of fumonisins, is one of the most toxic mycotoxins produced mainly by Fusarium proliferatum and Fusarium verticillioide. FB1 has caused extensive contamination worldwide, mainly in corn, rice, wheat, and their products, while it also poses a health risk and is toxic to animals and human. It has been shown to cause oxidative stress, endoplasmic reticulum stress, cellular autophagy, and apoptosis. This review focuses on the current stage of FB1 contamination, its toxic effects of acute toxicity, immunotoxicity, organ toxicity, and reproductive toxicity on animals and humans. The potential toxic mechanisms of FB1 are discussed. One of the main aims of the work is to provide a reliable reference strategy for understanding the occurrence and toxicity of FB1.

引用

页数：21

共 157 条

[1] Interaction of aflatoxin B1 and fumonisin B1 in mice causes immunotoxicity and oxidative stress: Possible protective role using lactic acid bacteria [J].

Abbes, Samir ;

Ben Salah-Abbes, Jalila ;

Jebali, Rania ;

Ben Younes, Ridha ;

Oueslati, Ridha .

JOURNAL OF IMMUNOTOXICOLOGY, 2016, 13 (01) :46-54

[2] Prevention of fumonisin-indnced maternal and developmental toxicity in rats by certain plant extracts [J].

Abde-Wahhab, MA ;

Hassan, AM ;

Amer, HA ;

Naguib, KM .

JOURNAL OF APPLIED TOXICOLOGY, 2004, 24 (06) :469-474

[3] A review on incidence and toxicity of fumonisins [J].

Ahangarkani, Fatemeh ;

Rouhi, Samaneh ;

Azizi, Issa Gholamour .

TOXIN REVIEWS, 2014, 33 (03) :95-100

[4] Porcine Hepatic Response to Fumonisin B1 in a Short Exposure Period: Fatty Acid Profile and Clinical Investigations [J].

Ali, Omeralfaroug ;

Szabo-Fodor, Judit ;

Febel, Hedvig ;

Mezes, Miklos ;

Balogh, Krisztian ;

Glavits, Robert ;

Kovacs, Melinda ;

Zantomasi, Arianna ;

Szabo, Andras .

TOXINS, 2019, 11 (11)

[5] Fumonisin B1 Contamination of Cereals and Risk of Esophageal Cancer in a High Risk Area in Northeastern Iran [J].

Alizadeh, Ali Mohammad ;

Roshandel, Gholamreza ;

Roudbarmohammadi, Shahla ;

Roudbary, Maryam ;

Sohanaki, Hamid ;

Ghiasian, Seyed Amir ;

Taherkhani, Amir ;

Semnani, Shahryar ;

Aghasi, Maryam .

ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, 2012, 13 (06) :2625-2628

[6] Four-Year Surveillance for Ochratoxin A and Fumonisins in Retail Foods in Japan [J].

Aoyama, Koji ;

Nakajima, Masahiro ;

Tabata, Setsuko ;

Ishikuro, Eiichi ;

Tanaka, Toshitsugu ;

Norizuki, Hiroko ;

Itoh, Yoshinori ;

Fujita, Kazuhiro ;

Kai, Shigemi ;

Tsutsumi, Toru ;

Takahashi, Masanori ;

Tanaka, Hiroki ;

Iizuka, Seiichiro ;

Ogiso, Motoki ;

Maeda, Mamoru ;

Yamaguchi, Shigeaki ;

Sugiyama, Kei-ichi ;

Sugita-Konishi, Yoshiko ;

Kumagai, Susumu .

JOURNAL OF FOOD PROTECTION, 2010, 73 (02) :344-352

[7] Occurrence of Mycotoxins in Swine Feeding from Spain [J].

Arroyo-Manzanares, Natalia ;

Rodriguez-Estevez, Vicente ;

Arenas-Fernandez, Placido ;

Garcia-Campana, Ana M. ;

Gamiz-Gracia, Laura .

TOXINS, 2019, 11 (06)

[8] Fumonisin B1 alters global m6A RNA methylation and epigenetically regulates Keap1-Nrf2 signaling in human hepatoma (HepG2) cells [J].

Arumugam, Thilona ;

Ghazi, Terisha ;

Chuturgoon, Anil A. .

ARCHIVES OF TOXICOLOGY, 2021, 95 (04) :1367-1378

[9] Fumonisin B1 Epigenetically Regulates PTEN Expression and Modulates DNA Damage Checkpoint Regulation in HepG2 Liver Cells [J].

Arumugam, Thilona ;

Ghazi, Terisha ;

Chuturgoon, Anil .

TOXINS, 2020, 12 (10)

[10] Fumonisin B1-induced oxidative stress triggers Nrf2-mediated antioxidant response in human hepatocellular carcinoma (HepG2) cells [J].

Arumugam, Thilona ;

Pillay, Yashodani ;

Ghazi, Terisha ;

Nagiah, Savania ;

Abdul, Naeem Sheik ;

Chuturgoon, Anil A. .

MYCOTOXIN RESEARCH, 2019, 35 (01) :99-109

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