Research Progress on Fumonisin B1 Contamination and Toxicity: A Review

被引：112

作者：

Chen, Jia ^{[1
]}

Wen, Jun ^{[1
]}

Tang, Yating ^{[1
]}

Shi, Jichao ^{[2
]}

Mu, Guodong ^{[3
]}

Yan, Rong ^{[1
]}

Cai, Jing ^{[1
]}

Long, Miao ^{[1
]}

机构：

[1] Shenyang Agr Univ, Coll Anim Sci & Vet Med, Shenyang 110866, Peoples R China

[2] Liaoning Serv Dev Ctr, Shenyang 110032, Peoples R China

[3] Jilin Ctr Anim Dis Control & Prevent, 4510 Xian Rd, Changchun 130062, Peoples R China

来源：

MOLECULES | 2021年 / 26卷 / 17期

基金：

中国国家自然科学基金;

关键词：

fumonisin B1; toxicity; mechanism; contamination; review; NEURAL-TUBE DEFECTS; ESOPHAGEAL EPITHELIAL-CELLS; SPHINGOLIPID METABOLISM; RAT-KIDNEY; IN-VIVO; DEVELOPMENTAL TOXICITY; HUMAN KERATINOCYTES; DIETARY EXPOSURE; AFLATOXIN B-1; FUSARIUM SPP;

D O I：

10.3390/molecules26175238

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Fumonisin B1 (FB1), belonging to the member of fumonisins, is one of the most toxic mycotoxins produced mainly by Fusarium proliferatum and Fusarium verticillioide. FB1 has caused extensive contamination worldwide, mainly in corn, rice, wheat, and their products, while it also poses a health risk and is toxic to animals and human. It has been shown to cause oxidative stress, endoplasmic reticulum stress, cellular autophagy, and apoptosis. This review focuses on the current stage of FB1 contamination, its toxic effects of acute toxicity, immunotoxicity, organ toxicity, and reproductive toxicity on animals and humans. The potential toxic mechanisms of FB1 are discussed. One of the main aims of the work is to provide a reliable reference strategy for understanding the occurrence and toxicity of FB1.

引用

页数：21

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